6PBC
Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | polymer | 1176 | 135956.9 | 1 | UniProt (G3V845) UniProt (P10686) Pfam (PF00169) Pfam (PF00388) Pfam (PF00017) Pfam (PF00018) Pfam (PF00387) Pfam (PF00168) | Rattus norvegicus (Rat) | Phosphoinositide phospholipase C-gamma-1,Phospholipase C-gamma-1,PLC-gamma-1 |
| 2 | B (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 3 | C (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | D (A) | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence modifications
A: 21 - 765 (UniProt: G3V845)
A: 791 - 1215 (UniProt: P10686)
| PDB | External Database | Details |
|---|---|---|
| Ser 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Ala 20 | - | expression tag |
| Ser 788 | - | linker |
| Gly 789 | - | linker |
| Ser 790 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 135956.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 63.1 | |
| All* | Total formula weight | 136020.0 |
