8SSN

Abl kinase in complex with SKI and asciminib

Summary for 8SSN

• Entry DOI: 10.2210/pdb8ssn/pdb
• Descriptor: Tyrosine-protein kinase ABL1, asciminib, 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine, ... (7 entities in total)
• Functional Keywords: complex, kinase, double drugging, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 104664.16

Authors

Ludewig, H.,Kim, C.,Kern, D. (deposition date: 2023-05-08, release date: 2023-09-06)

• Primary citation: Kim, C.,Ludewig, H.,Hadzipasic, A.,Kutter, S.,Nguyen, V.,Kern, D.; A biophysical framework for double-drugging kinases.; Proc.Natl.Acad.Sci.USA, 120:e2304611120-e2304611120, 2023; PubMed: 37590418; DOI: 10.1073/pnas.2304611120

Experimental method

X-RAY DIFFRACTION (2.86 Å)