8SSN
Abl kinase in complex with SKI and asciminib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein kinase ABL1 | polymer | 448 | 51190.8 | 2 | UniProt (P00519) Pfam (PF00018) Pfam (PF00017) Pfam (PF07714) | Homo sapiens (human) | Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Proto-oncogene c-Abl,p150 |
| 2 | C, K (A, B) | asciminib | non-polymer | 449.8 | 2 | Chemie (AY7) | |||
| 3 | D, L (A, B) | 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine | non-polymer | 373.4 | 2 | Chemie (SKI) | |||
| 4 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | F, G, M (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 6 | H, I, J, N (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 7 | O, P (A, B) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A, B: 83 - 529 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 82 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 102381.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2282.7 | |
| All* | Total formula weight | 104664.2 |
