2PZ1

Crystal Structure of Auto-inhibited Asef

Summary for 2PZ1

Entry DOI	10.2210/pdb2pz1/pdb
Descriptor	Rho guanine nucleotide exchange factor 4 (2 entities in total)
Functional Keywords	helical bundle, beta barrel, beta sandwich, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Isoform 3: Cytoplasm: Q9NR80
Total number of polymer chains	1
Total formula weight	53937.78
Authors	Betts, L.,Sondek, J.,Rossman, K.L. (deposition date: 2007-05-17, release date: 2007-08-21, Last modification date: 2024-02-21)
Primary citation	Mitin, N.,Betts, L.,Yohe, M.E.,Der, C.J.,Sondek, J.,Rossman, K.L. Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nat.Struct.Mol.Biol., 14:814-823, 2007 Cited by PubMed: 17704816 DOI: 10.1038/nsmb1290 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation