8GMB
Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible)
Summary for 8GMB
Entry DOI | 10.2210/pdb8gmb/pdb |
Descriptor | Tyrosine-protein kinase BTK, 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one (2 entities in total) |
Functional Keywords | atp-binding, lipid-binding, transcription regulation, immunity, transferase |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 1 |
Total formula weight | 77065.14 |
Authors | Lin, D.Y.,Andreotti, A.H. (deposition date: 2023-03-24, release date: 2023-08-16, Last modification date: 2024-01-31) |
Primary citation | Lin, D.Y.,Kueffer, L.E.,Juneja, P.,Wales, T.E.,Engen, J.R.,Andreotti, A.H. Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12:-, 2024 Cited by PubMed: 38189455DOI: 10.7554/eLife.89489 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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