8GMB

Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein kinase BTK	polymer	659	76400.3	1	UniProt (P35991) Pfam (PF00169) Pfam (PF00779) Pfam (PF00018) Pfam (PF00017) Pfam (PF07714)	Mus musculus (house mouse)	Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase,Kinase EMB
2	B (A)	2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one	non-polymer		664.8	1	Chemie (9AJ)

Sequence modifications

A: 1 - 659 (UniProt: P35991)

PDB	External Database	Details
Ala 298	Glu 298	engineered mutation
Ala 300	Lys 300	engineered mutation
Ala 301	Glu 301	engineered mutation
Pro 384	Ala 384	engineered mutation
Pro 386	Ser 386	engineered mutation
Pro 387	Thr 387	engineered mutation
Pro 388	Ala 388	engineered mutation
Phe 390	Leu 390	engineered mutation
Arg 430	Lys 430	engineered mutation
Met 542	Leu 542	engineered mutation
Thr 543	Ser 543	engineered mutation
Thr 555	Val 555	engineered mutation
Lys 562	Arg 562	engineered mutation
Ala 564	Ser 564	engineered mutation
Ser 565	Pro 565	engineered mutation
Pro 617	Tyr 617	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	76400.3
Non-Polymers*	Number of molecules	1
	Total formula weight	664.8
All*	Total formula weight	77065.1

*Water molecules are not included.