7YQE

Structure of human SRC regulatory domains in complex with the C-terminal PRRP motifs of GPR54.

Summary for 7YQE

Entry DOI	10.2210/pdb7yqe/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase Src,KiSS-1 receptor (1 entity in total)
Functional Keywords	protein kinase-like, signaling, complex, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	42809.82
Authors	Song, G.,Xu, S. (deposition date: 2022-08-06, release date: 2023-08-16, Last modification date: 2024-02-28)
Primary citation	Li, Z.,Yang, X.,Fu, R.,Wu, Z.,Xu, S.,Jiao, J.,Qian, M.,Zhang, L.,Wu, C.,Xie, T.,Yao, J.,Wu, Z.,Li, W.,Ma, G.,You, Y.,Chen, Y.,Zhang, H.K.,Cheng, Y.,Tang, X.,Wu, P.,Lian, G.,Wei, H.,Zhao, J.,Xu, J.,Ai, L.,Siwko, S.,Wang, Y.,Ding, J.,Song, G.,Luo, J.,Liu, M.,Xiao, J. Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nat Commun, 15:1300-1300, 2024 Cited by PubMed: 38346942 DOI: 10.1038/s41467-024-44852-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.5 Å)

Structure validation