4XI2

Crystal Structure of an auto-inhibited form of Bruton's Tryrosine Kinase

Summary for 4XI2

Entry DOI	10.2210/pdb4xi2/pdb
Descriptor	Tyrosine-protein kinase BTK, GOLD ION (2 entities in total)
Functional Keywords	kinase, phosphorylation, auto-inhibited, b-cell development, x-linked agammaglobulinemia, transferase
Biological source	Mus musculus (Mouse)
Cellular location	Cytoplasm : P35991
Total number of polymer chains	1
Total formula weight	52192.75
Authors	Vogan, E.M.,Harrison, S.C. (deposition date: 2015-01-06, release date: 2015-02-25, Last modification date: 2024-02-28)
Primary citation	Wang, Q.,Vogan, E.M.,Nocka, L.M.,Rosen, C.E.,Zorn, J.A.,Harrison, S.C.,Kuriyan, J. Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4:-, 2015 Cited by PubMed: 25699547 DOI: 10.7554/eLife.06074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation