4XI2

Crystal Structure of an auto-inhibited form of Bruton's Tryrosine Kinase

Summary for 4XI2

DescriptorTyrosine-protein kinase BTK, GOLD ION (2 entities in total)
Functional Keywordskinase, phosphorylation, auto-inhibited, b-cell development, x-linked agammaglobulinemia, transferase
Biological sourceMus musculus (Mouse)
Cellular locationCytoplasm  P35991
Total number of polymer chains1
Total molecular weight52192.75
Authors
Vogan, E.M.,Harrison, S.C. (deposition date: 2015-01-06, release date: 2015-02-25, Last modification date: 2015-03-11)
Primary citation
Wang, Q.,Vogan, E.M.,Nocka, L.M.,Rosen, C.E.,Zorn, J.A.,Harrison, S.C.,Kuriyan, J.
Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.
Elife, 4:-, 2015
PubMed: 25699547 (PDB entries with the same primary citation)
DOI: 10.7554/eLife.06074
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.261102.4%7.2%16.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4xi2
no rotation
Molmil generated image of 4xi2
rotated about x axis by 90°
Molmil generated image of 4xi2
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 4xi2
no rotation
Molmil generated image of 4xi2
rotated about x axis by 90°
Molmil generated image of 4xi2
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4xi2.pdb1.gz [433.08 KB])
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