8JN9

Crystal structure of c-Src in complex with covalent inhibitor LW-Srci-8

Summary for 8JN9

• Entry DOI: 10.2210/pdb8jn9/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, N-[(1R)-1-[3,5-bis(fluoranyl)phenyl]-2-(cyclopentylamino)-2-oxidanylidene-ethyl]-N-cyclopropyl-prop-2-enamide (3 entities in total)
• Functional Keywords: src kinase, covalent inhibitor, auto-phosphorylation site, oncoprotein-inhibitor complex, oncoprotein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 60334.94

Authors

Zhang, H.M.,Luo, C. (deposition date: 2023-06-06, release date: 2024-06-12)

• Primary citation: Zhang, H.M.,Luo, C.; The crystal structure of c-Src in complex with covalent inhibitor LW-Srci-8; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.724 Å)