1QCF
CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR
Summary for 1QCF
Entry DOI | 10.2210/pdb1qcf/pdb |
Related | 1AD5 |
Descriptor | Tyrosine-protein kinase HCK, 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE (3 entities in total) |
Functional Keywords | tyrosine kinase-inhibitor complex, down-regulated kinase, ordered activation loop, tyrosine kinase |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Lysosome. Isoform 2: Cell membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle: P08631 |
Total number of polymer chains | 1 |
Total formula weight | 52281.58 |
Authors | Schindler, T.,Sicheri, F.,Pico, A.,Gazit, A.,Levitzki, A.,Kuriyan, J. (deposition date: 1999-05-04, release date: 1999-06-08, Last modification date: 2022-12-21) |
Primary citation | Schindler, T.,Sicheri, F.,Pico, A.,Gazit, A.,Levitzki, A.,Kuriyan, J. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol.Cell, 3:639-648, 1999 Cited by PubMed: 10360180DOI: 10.1016/S1097-2765(00)80357-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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