1QCF
CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase HCK | polymer | 454 | 52000.2 | 1 | UniProt (P08631) Pfam (PF00018) Pfam (PF00017) Pfam (PF07714) In PDB | Homo sapiens (human) | Hematopoietic cell kinase,Hemopoietic cell kinase,p59-HCK/p60-HCK,p59Hck,p61Hck |
| 2 | A | 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE | non-polymer | 281.4 | 1 | Chemie (PP1) | |||
| 3 | water | water | 18.0 | 312 | Chemie (HOH) |
Sequence modifications
A: 84 - 531 (UniProt: P08631)
| PDB | External Database | Details |
|---|---|---|
| Gly 76 | - | expression tag |
| Ala 77 | - | expression tag |
| Met 78 | - | expression tag |
| Gly 79 | - | expression tag |
| Ser 80 | - | expression tag |
| Gly 81 | - | expression tag |
| Ile 82 | - | expression tag |
| Arg 83 | - | expression tag |
| Glu 528 | Gln 523 | engineered mutation |
| Glu 529 | Gln 524 | engineered mutation |
| Ile 530 | Gln 525 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 52000.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 281.4 | |
| All* | Total formula weight | 52281.6 |
