PDB: 156 件ウェブページステータス検索Chemie searchBIRD

---

7SJ3	Structure of CDK4-Cyclin D3 bound to abemaciclib 分子名称: Cyclin-dependent kinase 4, G1/S-specific cyclin-D3, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine 著者 Hilgers, M.T, Pelletier, L.A. 登録日 2021-10-15 公開日 2022-11-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Structure of CDK4-Cyclin D3 bound to abemaciclib To Be Published
7QHL	Crystal structure of Cyclin-dependent kinase 2/cyclin A in complex with 3,5,7-Substituted pyrazolo[4,3-d]pyrimidine inhibitor 24 分子名称: 1,2-ETHANEDIOL, 5-(2-amino-1-ethyl)thio-3-cyclobutyl-7-[4-(pyrazol-1-yl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine, Cyclin-A2, ... 著者 Djukic, S, Skerlova, J, Rezacova, P. 登録日 2021-12-13 公開日 2022-07-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 3,5,7-Substituted Pyrazolo[4,3- d ]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders. J.Med.Chem., 65, 2022
5CYI	CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300) 分子名称: 6-(cyclohexylmethoxy)-N-[4-(ethylsulfonyl)phenyl]-9H-purin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2 著者 Anscombe, E, Meschini, E, Vidal, R.M, Martin, M.P, Staunton, D, Geitmann, M, Danielson, U.H, Stanley, W.A, Wang, L.Z, Reuillon, T, Golding, B.T, Cano, C, Newell, D.R, Noble, M.E.M, Wedge, S.R, Endicott, J.A, Griffin, R.J. 登録日 2015-07-30 公開日 2015-09-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Identification and Characterization of an Irreversible Inhibitor of CDK2. Chem.Biol., 22, 2015
7ACK	CDK2/cyclin A2 in complex with an imidazo[1,2-c]pyrimidin-5-one inhibitor 分子名称: 1,2-ETHANEDIOL, 8-cyclohexyl-6~{H}-imidazo[1,2-c]pyrimidin-5-one, Cyclin-A2, ... 著者 Skerlova, J, Pachl, P, Rezacova, P. 登録日 2020-09-11 公開日 2021-03-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure. Eur.J.Med.Chem., 216, 2021
7XQK	The Crystal Structure of CDK3 and CyclinE1 Complex from Biortus. 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, G1/S-specific cyclin-E1, GLYCEROL, ... 著者 Gui, W, Wang, F, Cheng, W, Gao, J, Huang, Y. 登録日 2022-05-07 公開日 2023-05-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 The Crystal Structure of CDK3 and CyclinE1 Complex from Biortus. To Be Published
8ROZ	Cryo-EM structure of CDK2-cyclin A in complex with CDC25A 分子名称: Cyclin-A2, Cyclin-dependent kinase 2, M-phase inducer phosphatase 1 著者 Rowland, R.J, Noble, M.E.M, Endicott, J.A. 登録日 2024-01-12 公開日 2024-05-29 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Cryo-EM structure of the CDK2-cyclin A-CDC25A Complex To Be Published
3TNW	Structure of CDK2/cyclin A in complex with CAN508 分子名称: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Baumli, S, Hole, A.J, Endicott, J.A. 登録日 2011-09-02 公開日 2012-02-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508. Acs Chem.Biol., 7, 2012
6ATH	Cdk2/cyclin A/p27-KID-deltaC 分子名称: Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, ... 著者 White, S.W, Yun, M. 登録日 2017-08-29 公開日 2018-09-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation. Nat Commun, 10, 2019
3MY5	CDk2/cyclinA in complex with DRB 分子名称: 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole, Cell division protein kinase 2, Cyclin-A2, ... 著者 Baumli, S, Johnson, L.N. 登録日 2010-05-09 公開日 2010-09-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Halogen bonds form the basis for selective P-TEFb inhibition by DRB Chem.Biol., 17, 2010
5NEV	CDK2/Cyclin A in complex with compound 73 分子名称: 4-[[6-(3-phenylphenyl)-7~{H}-purin-2-yl]amino]benzenesulfonamide, Cyclin-A2, Cyclin-dependent kinase 2 著者 Coxon, C.R, Anscombe, E, Harnor, S.J, Martin, M.P, Carbain, B, Hardcastle, I.R, Harlow, L.K, Korolchuk, S, Matheson, C.J, Noble, M.E.M, Newell, D.R, Turner, D, Sivaprakasam, M, Wang, L.Z, Wong, C, Golding, B.T, Griffin, R.J, Cano, G. 登録日 2017-03-12 公開日 2017-03-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J. Med. Chem., 60, 2017
6SG4	Structure of CDK2/cyclin A M246Q, S247EN 分子名称: Cyclin-A2, Cyclin-dependent kinase 2 著者 Salamina, M, Basle, A, Massa, B, Noble, M.E.M, Endicott, J.A. 登録日 2019-08-02 公開日 2021-01-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation. J.Mol.Biol., 433, 2021
4I3Z	Structure of pCDK2/CyclinA bound to ADP and 2 Magnesium ions 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Cyclin-A2, ... 著者 Jacobsen, D.M, Bao, Z.-Q, O'Brien, P.J, Brooks, C.L, Young, M.A. 登録日 2012-11-27 公開日 2012-12-26 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Price To Be Paid for Two-Metal Catalysis: Magnesium Ions That Accelerate Chemistry Unavoidably Limit Product Release from a Protein Kinase J.Am.Chem.Soc., 134, 2012
3F5X	CDK-2-Cyclin complex with indazole inhibitor 9 bound at its active site 分子名称: 4-{3-[7-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline, Cell division protein kinase 2, Cyclin-A2, ... 著者 Kiefer, J.R, Day, J.E, Caspers, N.L, Mathis, K.J, Kretzmer, K.K, Weinberg, R.A, Reitz, B.A, Stegeman, R.A, Trujillo, J.I, Huang, W, Thorarensen, A, Xing, L, Wrightstone, A, Christine, L, Compton, R, Li, X. 登録日 2008-11-04 公開日 2009-02-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg.Med.Chem.Lett., 19, 2009
4II5	Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Jacobsen, D.M, Bao, Z.-Q, O'Brien, P.J, Brooks III, C.L, Young, M.A. 登録日 2012-12-19 公開日 2013-01-23 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Price to be paid for two-metal catalysis: Magnesium ions that accelerate chemistry unavoidably limit product release from a PROTEIN KINASE J.Am.Chem.Soc., 134, 2012
1QMZ	PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN A, ... 著者 Brown, N.R, Noble, M.E.M, Endicott, J.A, Johnson, L.N. 登録日 1999-10-11 公開日 1999-12-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The Structural Basis for Specificity of Substrate and Recruitment Peptides for Cyclin-Dependent Kinases Nat.Cell Biol., 1, 1999
5HQ0	Ternary complex of human proteins CDK1, Cyclin B and CKS2, bound to an inhibitor 分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ... 著者 Noble, M.E, Martin, M.P, Korolchuk, S, Brown, N.R, Moukhametzianov, R, Stanley, W.A. 登録日 2016-01-21 公開日 2016-03-02 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat Commun, 6, 2015
8VQ4	CDK2-CyclinE1 in complex with allosteric inhibitor I-125A. 分子名称: (8R)-6-(1-benzyl-1H-pyrazole-4-carbonyl)-N-[(2S,3R)-3-(2-cyclohexylethoxy)-1-(methylamino)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 著者 Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B. 登録日 2024-01-17 公開日 2024-01-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Expanding the ligandable proteome by paralog hopping with covalent probes. Biorxiv, 2024
8VQ3	CDK2-CyclinE1 in complex with allosteric inhibitor I-198. 分子名称: (8R)-N-[(2S,3R)-3-(cyclohexylmethoxy)-1-(morpholin-4-yl)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-6-(1,3-thiazole-5-carbonyl)-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 著者 Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B. 登録日 2024-01-17 公開日 2024-01-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Expanding the ligandable proteome by paralog hopping with covalent probes. Biorxiv, 2024
3G33	Crystal structure of CDK4/cyclin D3 分子名称: CCND3 protein, Cell division protein kinase 4 著者 Takaki, T, Echalier, A, Brown, N.R, Hunt, T, Endicott, J.A, Noble, M.E.M. 登録日 2009-02-01 公開日 2009-03-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The structure of CDK4/cyclin D3 has implications for models of CDK activation. Proc.Natl.Acad.Sci.USA, 106, 2009
3QHW	Structure of a pCDK2/CyclinA transition-state mimic 分子名称: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, CDK2 substrate peptide: PKTPKKAKKL, ... 著者 Young, M.A, Jacobsen, D.M, Bao, Z.Q. 登録日 2011-01-26 公開日 2011-05-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis. Structure, 19, 2011
3QHR	Structure of a pCDK2/CyclinA transition-state mimic 分子名称: ADENOSINE-5'-DIPHOSPHATE, CDK2 substrate peptide: PKTPKKAKKL, CHLORIDE ION, ... 著者 Young, M.A, Jacobsen, D.M, Bao, Z.Q. 登録日 2011-01-26 公開日 2011-05-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis. Structure, 19, 2011
4Y72	Human CDK1/CyclinB1/CKS2 With Inhibitor 分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ... 著者 Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A. 登録日 2015-02-13 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat Commun, 6, 2015
4YC3	CDK1/CyclinB1/CKS2 Apo 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, ... 著者 Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A. 登録日 2015-02-19 公開日 2016-04-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat Commun, 6, 2015
5IF1	Crystal structure apo CDK2/cyclin A 分子名称: Cyclin-A2, Cyclin-dependent kinase 2 著者 Ayaz, P, Andres, D, Kwiatkowski, D.A, Kolbe, C, Lienau, P, Siemeister, G, Luecking, U, Stegmann, C.M. 登録日 2016-02-25 公開日 2016-04-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9. Acs Chem.Biol., 11, 2016
1URC	Cyclin A binding groove inhibitor Ace-Arg-Lys-Leu-Phe-Gly 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, PEPTIDE INHIBITOR 著者 Kontopidis, G, Andrews, M, McInnes, C, Cowan, A, Powers, H, Innes, L, Plater, A, Griffiths, G, Paterson, D, Zheleva, D, Lane, D, Green, S, Walkinshaw, M, Fischer, P. 登録日 2003-10-28 公開日 2003-10-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes. Org. Biomol. Chem., 2, 2004

 

1234567>