6SG4

Structure of CDK2/cyclin A M246Q, S247EN

Summary for 6SG4

Entry DOI	10.2210/pdb6sg4/pdb
Descriptor	Cyclin-dependent kinase 2, Cyclin-A2 (3 entities in total)
Functional Keywords	cyclin-dependent kinases, cancer, cyclin a, cdk2, cell cycle, skp2
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	130927.16
Authors	Salamina, M.,Basle, A.,Massa, B.,Noble, M.E.M.,Endicott, J.A. (deposition date: 2019-08-02, release date: 2021-01-27, Last modification date: 2024-01-24)
Primary citation	Salamina, M.,Montefiore, B.C.,Liu, M.,Wood, D.J.,Heath, R.,Ault, J.R.,Wang, L.Z.,Korolchuk, S.,Basle, A.,Pastok, M.W.,Reeks, J.,Tatum, N.J.,Sobott, F.,Arold, S.T.,Pagano, M.,Noble, M.E.M.,Endicott, J.A. Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation. J.Mol.Biol., 433:166795-166795, 2021 Cited by PubMed: 33422522 DOI: 10.1016/j.jmb.2020.166795 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation