6SG4
Structure of CDK2/cyclin A M246Q, S247EN
Summary for 6SG4
Entry DOI | 10.2210/pdb6sg4/pdb |
Descriptor | Cyclin-dependent kinase 2, Cyclin-A2 (3 entities in total) |
Functional Keywords | cyclin-dependent kinases, cancer, cyclin a, cdk2, cell cycle, skp2 |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 130927.16 |
Authors | Salamina, M.,Basle, A.,Massa, B.,Noble, M.E.M.,Endicott, J.A. (deposition date: 2019-08-02, release date: 2021-01-27, Last modification date: 2024-01-24) |
Primary citation | Salamina, M.,Montefiore, B.C.,Liu, M.,Wood, D.J.,Heath, R.,Ault, J.R.,Wang, L.Z.,Korolchuk, S.,Basle, A.,Pastok, M.W.,Reeks, J.,Tatum, N.J.,Sobott, F.,Arold, S.T.,Pagano, M.,Noble, M.E.M.,Endicott, J.A. Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation. J.Mol.Biol., 433:166795-166795, 2021 Cited by PubMed: 33422522DOI: 10.1016/j.jmb.2020.166795 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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