6SG4

Structure of CDK2/cyclin A M246Q, S247EN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Cyclin-dependent kinase 2	polymer	302	34354.8	2	UniProt (P24941) Pfam (PF00069)	Homo sapiens (Human)	Cell division protein kinase 2,p33 protein kinase
2	B, D (B, D)	Cyclin-A2	polymer	269	31108.8	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984)	Homo sapiens (Human)	Cyclin-A,Cyclin A
3	E, F, G, H (A, B, C, D)	water	water		18.0	97	Chemie (HOH)

Sequence modifications

A, C: 1 - 298 (UniProt: P24941)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

B, D: 174 - 433 (UniProt: P20248)

PDB	External Database	Details
Met 173	-	initiating methionine
Gln 246	Met 246	conflict
Glu 247	-	insertion
Asn 248	Ser 247	conflict
Leu 434	-	expression tag
Glu 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
His 441	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	130927.2
All*	Total formula weight	130927.2

*Water molecules are not included.