7ACK

CDK2/cyclin A2 in complex with an imidazo[1,2-c]pyrimidin-5-one inhibitor

Summary for 7ACK

Entry DOI	10.2210/pdb7ack/pdb
Descriptor	Cyclin-dependent kinase 2, Cyclin-A2, 8-cyclohexyl-6~{H}-imidazo[1,2-c]pyrimidin-5-one, ... (7 entities in total)
Functional Keywords	cyclin-dependent kinase 2, substituted imidazo[1, 2-c]pyrimidin-5-one, inhibitor, cell cycle
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	128823.02
Authors	Skerlova, J.,Pachl, P.,Rezacova, P. (deposition date: 2020-09-11, release date: 2021-03-24, Last modification date: 2024-01-31)
Primary citation	Jansa, J.,Jorda, R.,Skerlova, J.,Pachl, P.,Perina, M.,Reznickova, E.,Heger, T.,Gucky, T.,Rezacova, P.,Lycka, A.,Krystof, V. Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure. Eur.J.Med.Chem., 216:113309-113309, 2021 Cited by PubMed: 33711765 DOI: 10.1016/j.ejmech.2021.113309 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation