3QHR

Structure of a pCDK2/CyclinA transition-state mimic

Summary for 3QHR

• Entry DOI: 10.2210/pdb3qhr/pdb
• Related: 3QHW
• Descriptor: Cell division protein kinase 2, Cyclin-A2, CDK2 substrate peptide: PKTPKKAKKL, ... (9 entities in total)
• Functional Keywords: kinase catalytic domain, protein kinase, cyclin, phosphorylated thr-160, transferase-protein binding complex, transferase/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P51943
• Total number of polymer chains: 8
• Total formula weight: 134959.99

Authors

Young, M.A.,Jacobsen, D.M.,Bao, Z.Q. (deposition date: 2011-01-26, release date: 2011-05-25, Last modification date: 2024-04-03)

• Primary citation: Bao, Z.Q.,Jacobsen, D.M.,Young, M.A.; Briefly Bound to Activate: Transient Binding of a Second Catalytic Magnesium Activates the Structure and Dynamics of CDK2 Kinase for Catalysis.; Structure, 19:675-690, 2011; PubMed: 21565702; DOI: 10.1016/j.str.2011.02.016

Experimental method

X-RAY DIFFRACTION (2.17 Å)