3QHR

Structure of a pCDK2/CyclinA transition-state mimic

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Cell division protein kinase 2	polymer	298	33981.3	2	UniProt (P24941) Pfam (PF00069) In PDB	Homo sapiens (human)	p33 protein kinase
2	B, D	Cyclin-A2	polymer	261	29836.4	2	UniProt (P51943) Pfam (PF00134) Pfam (PF02984) In PDB	Mus musculus (mouse)	Cyclin-A
3	J, K, L, M	CDK2 substrate peptide: PKTPKKAKKL	polymer	10	1143.5	4
4	A, C	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
5	A, C	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
6	A, C	TRIFLUOROMAGNESATE	non-polymer		81.3	2	Chemie (MGF)
7	C, A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
8	C, D, K, A, B	GLYCEROL	non-polymer		92.1	17	Chemie (GOL)
9		water	water		18.0	601	Chemie (HOH)

Sequence modifications

A, C: 1 - 296 (UniProt: P24941)

PDB	External Database	Details
Gly -1	-	expression tag
His 0	-	expression tag

B, D: 173 - 432 (UniProt: P51943)

PDB	External Database	Details
Ser 172	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	132209.3
Non-Polymers*	Number of molecules	27
	Total formula weight	2750.7
All*	Total formula weight	134960.0

*Water molecules are not included.