3QHR
Structure of a pCDK2/CyclinA transition-state mimic
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Cell division protein kinase 2 | polymer | 298 | 33981.3 | 2 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | p33 protein kinase |
| 2 | B, D (B, D) | Cyclin-A2 | polymer | 261 | 29836.4 | 2 | UniProt (P51943) Pfam (PF00134) Pfam (PF02984) | Mus musculus (mouse) | Cyclin-A |
| 3 | E, F, G, H (J, K, L, M) | CDK2 substrate peptide: PKTPKKAKKL | polymer | 10 | 1143.5 | 4 | |||
| 4 | I, W (A, C) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 5 | J, K, X, Y (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 6 | L, Z (A, C) | TRIFLUOROMAGNESATE | non-polymer | 81.3 | 2 | Chemie (MGF) | |||
| 7 | AA, M (C, A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 8 | BA, CA, DA, EA, FA... (C, D, K, A, B) | GLYCEROL | non-polymer | 92.1 | 17 | Chemie (GOL) | |||
| 9 | JA, KA, LA, MA, NA... (A, B, C, D, J...) | water | water | 18.0 | 601 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 296 (UniProt: P24941)
B, D: 173 - 432 (UniProt: P51943)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 172 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 132209.3 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 2750.7 | |
| All* | Total formula weight | 134960.0 |
