4I3Z
Structure of pCDK2/CyclinA bound to ADP and 2 Magnesium ions
Summary for 4I3Z
| Entry DOI | 10.2210/pdb4i3z/pdb |
| Descriptor | Cyclin-dependent kinase 2, Cyclin-A2, ADENOSINE-5'-DIPHOSPHATE, ... (7 entities in total) |
| Functional Keywords | adp and magnesium binding, t160 phosphorylation, transferase-cell cycle complex, transferase/cell cycle |
| Biological source | Homo sapiens (human) More |
| Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 Nucleus : P51943 |
| Total number of polymer chains | 4 |
| Total formula weight | 128237.48 |
| Authors | Jacobsen, D.M.,Bao, Z.-Q.,O'Brien, P.J.,Brooks, C.L.,Young, M.A. (deposition date: 2012-11-27, release date: 2012-12-26, Last modification date: 2017-11-15) |
| Primary citation | Jacobsen, D.M.,Bao, Z.-Q.,O'Brien, P.J.,Brooks, C.L.,Young, M.A. Price To Be Paid for Two-Metal Catalysis: Magnesium Ions That Accelerate Chemistry Unavoidably Limit Product Release from a Protein Kinase J.Am.Chem.Soc., 134:15357-15370, 2012 Cited by PubMed: 22891849PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
Download full validation report
