8QMO
 
 | | Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ... | | 著者 | Kwong, H.S, Grandvuillemin, L, Sirounian, S, Ancelin, A, Lai-Kee-Him, J, Carivenc, C, Lancey, C, Ragan, T.J, Hesketh, E.L, Bourguet, W, Gruszczyk, J. | | 登録日 | 2023-09-24 | | 公開日 | 2024-01-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | | 主引用文献 | Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds.
J.Mol.Biol., 436, 2024
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8OVW
 | | Cryo-EM structure of CBF1-CCAN bound topologically to centromeric DNA | | 分子名称: | C0N3 DNA, Centromere-binding protein 1, Inner kinetochore subunit AME1, ... | | 著者 | Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. | | 登録日 | 2023-04-26 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere.
Sci Adv, 9, 2023
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8OW0
 | | Cryo-EM structure of CBF1-CCAN bound topologically to a centromeric CENP-A nucleosome | | 分子名称: | C0N3 DNA, Centromere-binding protein 1, Histone H2A.1, ... | | 著者 | Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. | | 登録日 | 2023-04-26 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere.
Sci Adv, 9, 2023
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8OW1
 | | Cryo-EM structure of the yeast Inner kinetochore bound to a CENP-A nucleosome. | | 分子名称: | C0N3, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... | | 著者 | Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. | | 登録日 | 2023-04-26 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere.
Sci Adv, 9, 2023
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8OTT
 | | MYC-MAX bound to a nucleosome at SHL+5.8 | | 分子名称: | DNA (144-MER), Histone H2A type 1-B/E, Histone H2A type 1-K, ... | | 著者 | Stoos, L, Michael, A.K, Kempf, G, Kater, L, Cavadini, S, Thoma, N. | | 登録日 | 2023-04-21 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
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8OTS
 | | OCT4 and MYC-MAX co-bound to a nucleosome | | 分子名称: | DNA (127-MER), Green fluorescent protein,POU domain, class 5, ... | | 著者 | Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N. | | 登録日 | 2023-04-21 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
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8OSL
 | | Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D classification and flexible refinement) | | 分子名称: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (147-MER), ... | | 著者 | Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N. | | 登録日 | 2023-04-19 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
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8OSK
 | | Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map) | | 分子名称: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... | | 著者 | Stoos, L, Michael, A.K, Kempf, G, Cavadini, S, Thoma, N.H. | | 登録日 | 2023-04-19 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
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8OSJ
 | | Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1) | | 分子名称: | Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ... | | 著者 | Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.H. | | 登録日 | 2023-04-19 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | | 主引用文献 | Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
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8OSB
 | | TWIST1-TCF4-ALX4 complex on specific DNA | | 分子名称: | DNA (25-MER), Homeobox protein aristaless-like 4, Transcription factor 4, ... | | 著者 | Morgunova, E, Kim, S, Popov, A, Wysocka, J, Taipale, J. | | 登録日 | 2023-04-18 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | DNA-guided transcription factor cooperativity shapes face and limb mesenchyme.
Cell, 187, 2024
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8IA3
 | | Crystal structure of human USF2 bHLHLZ domain in complex with DNA | | 分子名称: | DNA (5'-D(*GP*CP*GP*CP*GP*TP*CP*AP*CP*GP*TP*GP*CP*CP*CP*GP*TP*C)-3'), DNA (5'-D(P*GP*AP*CP*GP*GP*GP*CP*AP*CP*GP*TP*GP*AP*CP*GP*CP*GP*C)-3'), Upstream stimulatory factor 2 | | 著者 | Huang, C, Fang, P, Wang, J. | | 登録日 | 2023-02-07 | | 公開日 | 2023-09-20 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Tetramerization of upstream stimulating factor USF2 requires the elongated bent leucine zipper of the bHLH-LZ domain.
J.Biol.Chem., 299, 2023
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8H77
 | | Hsp90-AhR-p23-XAP2 complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ... | | 著者 | Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F. | | 登録日 | 2022-10-19 | | 公開日 | 2023-01-04 | | 最終更新日 | 2023-03-22 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of the cytosolic AhR complex.
Structure, 31, 2023
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7Y62
 | | Crystal structure of human TFEB HLHLZ domain | | 分子名称: | Transcription factor EB | | 著者 | Yang, G, Li, P, Lin, Y, Liu, Z, Sun, H, Zhao, Z, Fang, P, Wang, J. | | 登録日 | 2022-06-18 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7Y04
 | | Hsp90-AhR-p23 complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Aryl hydrocarbon receptor, BERYLLIUM TRIFLUORIDE ION, ... | | 著者 | Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F. | | 登録日 | 2022-06-03 | | 公開日 | 2023-01-04 | | 最終更新日 | 2023-03-22 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structure of the cytosolic AhR complex.
Structure, 31, 2023
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7ZUB
 | | Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex | | 分子名称: | (3~{Z})-3-(3-oxidanylidene-1~{H}-indol-2-ylidene)-1~{H}-indol-2-one, ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, ... | | 著者 | Gruszczyk, J, Savva, C.G, Lai-Kee-Him, J, Bous, J, Ancelin, A, Kwong, H.S, Grandvuillemin, L, Bourguet, W. | | 登録日 | 2022-05-12 | | 公開日 | 2022-11-23 | | 最終更新日 | 2022-12-07 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex.
Nat Commun, 13, 2022
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7UXC
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7UXH
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7UX2
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7XI4
 | | Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA | | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), ... | | 著者 | Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L. | | 登録日 | 2022-04-12 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (4.707 Å) | | 主引用文献 | Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7XI3
 | | Crystal Structure of the NPAS4-ARNT2 heterodimer in complex with DNA | | 分子名称: | Aryl hydrocarbon receptor nuclear translocator 2, DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), ... | | 著者 | Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L. | | 登録日 | 2022-04-11 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (4.274 Å) | | 主引用文献 | Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7XHV
 | | Crystal Structure of the NPAS4-ARNT heterodimer in complex with DNA | | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, DNA (5'-D(P*CP*CP*AP*TP*CP*AP*CP*TP*CP*AP*CP*GP*AP*CP*CP*T)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*TP*GP*AP*T)-3'), ... | | 著者 | Sun, X.N, Jing, L.Q, Li, F.W, Wu, D.L. | | 登録日 | 2022-04-10 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.996 Å) | | 主引用文献 | Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7Z5I
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7Z5K
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7WZ6
 | | Crystal structure of MyoD-E47 | | 分子名称: | Isoform E47 of Transcription factor E2-alpha, Myoblast determination protein 1 | | 著者 | Zhong, J, Huang, Y, Ma, J. | | 登録日 | 2022-02-17 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural basis of the bHLH domains of MyoD-E47 heterodimer.
Biochem.Biophys.Res.Commun., 621, 2022
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7W80
 | | Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan | | 分子名称: | 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | | 著者 | Ren, X, Diao, X, Zhuang, J, Wu, D. | | 登録日 | 2021-12-07 | | 公開日 | 2022-09-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.754 Å) | | 主引用文献 | Structural basis for the allosteric inhibition of hypoxia-inducible factor (HIF)-2 by belzutifan.
Mol.Pharmacol., 2022
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