8QMO

Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex

Summary for 8QMO

Entry DOI	10.2210/pdb8qmo/pdb
EMDB information	18498
Descriptor	Heat shock protein HSP 90-beta, AH receptor-interacting protein, Aryl hydrocarbon receptor, ... (7 entities in total)
Functional Keywords	detoxification, chemical pollutants, exposome, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	257085.08
Authors	Kwong, H.S.,Grandvuillemin, L.,Sirounian, S.,Ancelin, A.,Lai-Kee-Him, J.,Carivenc, C.,Lancey, C.,Ragan, T.J.,Hesketh, E.L.,Bourguet, W.,Gruszczyk, J. (deposition date: 2023-09-24, release date: 2024-01-10, Last modification date: 2024-02-28)
Primary citation	Kwong, H.S.,Paloni, M.,Grandvuillemin, L.,Sirounian, S.,Ancelin, A.,Lai-Kee-Him, J.,Grimaldi, M.,Carivenc, C.,Lancey, C.,Ragan, T.J.,Hesketh, E.L.,Balaguer, P.,Barducci, A.,Gruszczyk, J.,Bourguet, W. Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds. J.Mol.Biol., 436:168411-168411, 2024 Cited by PubMed: 38135181 DOI: 10.1016/j.jmb.2023.168411 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.76 Å)

Structure validation