8QMO

Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Heat shock protein HSP 90-beta	polymer	730	84213.1	2	UniProt (P08238) Pfam (PF13589) Pfam (PF00183)	Homo sapiens (human)	HSP 90,Heat shock 84 kDa,HSP 84,HSP84
2	C (C)	AH receptor-interacting protein	polymer	330	37691.0	1	UniProt (O00170) Pfam (PF00254)	Homo sapiens (human)	AIP,Aryl-hydrocarbon receptor-interacting protein,HBV X-associated protein 2,XAP-2,Immunophilin homolog ARA9
3	D (D)	Aryl hydrocarbon receptor	polymer	439	49492.6	1	UniProt (P35869) Pfam (PF00010) Pfam (PF00989) Pfam (PF08447)	Homo sapiens (human)
4	E, H (A, B)	MOLYBDATE ION	non-polymer		159.9	2	Chemie (MOO)
5	F, I (A, B)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
6	G, J (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
7	K (D)	benzo[a]pyrene	non-polymer		252.3	1	Chemie (W62)

Sequence modifications

A, B: 2 - 724 (UniProt: P08238)

PDB	External Database	Details
Met -5	-	initiating methionine
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag

D: 2 - 437 (UniProt: P35869)

PDB	External Database	Details
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	255609.9
Non-Polymers*	Number of molecules	7
	Total formula weight	1475.2
All*	Total formula weight	257085.1

*Water molecules are not included.