7ZUB

Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex

Summary for 7ZUB

Entry DOI	10.2210/pdb7zub/pdb
EMDB information	14971
Descriptor	Heat shock protein HSP 90-beta, AH receptor-interacting protein, Aryl hydrocarbon receptor, ... (7 entities in total)
Functional Keywords	complex, nuclear receptor, chemical pollutants, detoxification, cancer, gene regulation
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	257370.36
Authors	Gruszczyk, J.,Savva, C.G.,Lai-Kee-Him, J.,Bous, J.,Ancelin, A.,Kwong, H.S.,Grandvuillemin, L.,Bourguet, W. (deposition date: 2022-05-12, release date: 2022-11-23, Last modification date: 2022-12-07)
Primary citation	Gruszczyk, J.,Grandvuillemin, L.,Lai-Kee-Him, J.,Paloni, M.,Savva, C.G.,Germain, P.,Grimaldi, M.,Boulahtouf, A.,Kwong, H.S.,Bous, J.,Ancelin, A.,Bechara, C.,Barducci, A.,Balaguer, P.,Bourguet, W. Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex. Nat Commun, 13:7010-7010, 2022 Cited by PubMed: 36385050 DOI: 10.1038/s41467-022-34773-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.85 Å)

Structure validation