7ZUB

Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Heat shock protein HSP 90-beta	polymer	730	84213.1	2	UniProt (P08238) Pfam (PF13589) Pfam (PF00183) In PDB	Homo sapiens (human)	HSP 90,Heat shock 84 kDa,HSP 84,HSP84
2	C	AH receptor-interacting protein	polymer	330	37691.0	1	UniProt (O00170) Pfam (PF00254) In PDB	Homo sapiens (human)	AIP,Aryl-hydrocarbon receptor-interacting protein,HBV X-associated protein 2,XAP-2,Immunophilin homolog ARA9
3	D	Aryl hydrocarbon receptor	polymer	441	49767.9	1	UniProt (P35869) Pfam (PF00010) Pfam (PF00989) Pfam (PF08447) In PDB	Homo sapiens (human)	Ah receptor,AhR,Class E basic helix-loop-helix protein 76,bHLHe76
4	A, B	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
5	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	A, B	MOLYBDATE ION	non-polymer		159.9	2	Chemie (MOO)
7	D	(3~{Z})-3-(3-oxidanylidene-1~{H}-indol-2-ylidene)-1~{H}-indol-2-one	non-polymer		262.3	1	Chemie (JY6)

Sequence modifications

A, B: 2 - 724 (UniProt: P08238)

PDB	External Database	Details
Met -5	-	initiating methionine
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag

D: 1 - 437 (UniProt: P35869)

PDB	External Database	Details
Ala -3	-	expression tag
Pro -2	-	expression tag
Asn -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	255885.2
Non-Polymers*	Number of molecules	7
	Total formula weight	1485.2
All*	Total formula weight	257370.4

*Water molecules are not included.