8WQ9
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1OMY
| Crystal Structure of a Recombinant alpha-insect Toxin BmKaIT1 from the scorpion Buthus martensii Karsch | Descriptor: | ACETIC ACID, Alpha-neurotoxin TX12, CHLORIDE ION | Authors: | Huang, Y, Huang, Q, Chen, H, Tang, Y, Miyake, H, Kusunoki, M. | Deposit date: | 2003-02-26 | Release date: | 2003-09-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystallization and preliminary crystallographic study of rBmKalphaIT1, a recombinant alpha-insect toxin from the scorpion Buthus martensii Karsch. Acta Crystallogr.,Sect.D, 59, 2003
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6TQN
| rrn anti-termination complex without S4 | Descriptor: | 30S ribosomal protein S10, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Huang, Y.H, Wahl, M.C, Loll, B, Hilal, T, Said, N. | Deposit date: | 2019-12-17 | Release date: | 2020-08-05 | Last modified: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis. Mol.Cell, 79, 2020
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6TQO
| rrn anti-termination complex | Descriptor: | 30S ribosomal protein S10, 30S ribosomal protein S4, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Huang, Y.H, Wahl, M.C, Loll, B, Hilal, T, Said, N. | Deposit date: | 2019-12-17 | Release date: | 2020-08-05 | Last modified: | 2020-12-16 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure-Based Mechanisms of a Molecular RNA Polymerase/Chaperone Machine Required for Ribosome Biosynthesis. Mol.Cell, 79, 2020
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1KKG
| NMR Structure of Ribosome-Binding Factor A (RbfA) | Descriptor: | ribosome-binding factor A | Authors: | Huang, Y.J, Swapna, G.V.T, Rajan, P.K, Ke, H, Xia, B, Shukla, K, Inouye, M, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2001-12-07 | Release date: | 2003-03-18 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of Ribosome-binding Factor A (RbfA), A Cold-shock
Adaptation Protein from Escherichia coli J.Mol.Biol., 327, 2003
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5XGT
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7W4Y
| Crystal structure of PDE4D catalytic domain complexed with 33a | Descriptor: | (2R,4S)-6-ethyl-2-(2-hydroxyethyl)-2,8-dimethyl-4-(2-methylprop-1-enyl)-3,4-dihydropyrano[3,2-c][1,8]naphthyridin-5-one, MAGNESIUM ION, ZINC ION, ... | Authors: | Huang, Y.-Y, Luo, H.-B. | Deposit date: | 2021-11-29 | Release date: | 2022-03-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.10002947 Å) | Cite: | Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis. J.Med.Chem., 65, 2022
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7W4X
| Crystal structure of PDE4D catalytic domain complexed with 17 | Descriptor: | (2R,4S)-2-(2-hydroxyethyl)-2,6-dimethyl-4-(2-methylprop-1-enyl)-3,4-dihydropyrano[3,2-c][1,8]naphthyridin-5-one, MAGNESIUM ION, ZINC ION, ... | Authors: | Huang, Y.-Y, Luo, H.-B. | Deposit date: | 2021-11-29 | Release date: | 2022-03-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.20007324 Å) | Cite: | Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis. J.Med.Chem., 65, 2022
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4Q79
| Structure of a HG-derivative CsgG | Descriptor: | CsgG, MERCURY (II) ION | Authors: | Huang, Y, Zhang, C.X, Cao, B, Zhao, Y, Kou, Y, Ni, D. | Deposit date: | 2014-04-24 | Release date: | 2014-12-17 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the nonameric bacterial amyloid secretion channel Proc.Natl.Acad.Sci.USA, 111, 2014
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8UNF
| Cryo-EM structure of T4 Bacteriophage Clamp Loader with Sliding Clamp and DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Sliding clamp, ... | Authors: | Huang, Y, Marcus, K, Subramanian, S, Gee, L.C, Gorday, K, Ghaffari-Kashani, S, Luo, X, Zhang, L, O'Donnell, M, Subramanian, S, Kuriyan, J. | Deposit date: | 2023-10-18 | Release date: | 2023-12-13 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM. Nat.Struct.Mol.Biol., 31, 2024
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8UNH
| Cryo-EM structure of T4 Bacteriophage Clamp Loader with Sliding Clamp | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Sliding clamp, ... | Authors: | Huang, Y, Marcus, K, Subramanian, S, Gee, L.C, Gorday, K, Ghaffari-Kashani, S, Luo, X, Zhang, L, O'Donnell, M, Subramanian, S, Kuriyan, J. | Deposit date: | 2023-10-19 | Release date: | 2023-12-13 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM. Nat.Struct.Mol.Biol., 31, 2024
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1D2G
| CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE FROM RAT LIVER | Descriptor: | GLYCINE N-METHYLTRANSFERASE | Authors: | Huang, Y, Komoto, J, Takusagawa, F, Konishi, K, Takata, Y. | Deposit date: | 1999-10-08 | Release date: | 1999-10-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes. J.Mol.Biol., 298, 2000
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1D2C
| METHYLTRANSFERASE | Descriptor: | PROTEIN (GLYCINE N-METHYLTRANSFERASE) | Authors: | Huang, Y, Takusagawa, F. | Deposit date: | 1999-09-23 | Release date: | 1999-10-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes. J.Mol.Biol., 298, 2000
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4QXW
| Crystal structure of the human CEACAM1 membrane distal amino terminal (N)-domain | Descriptor: | Carcinoembryonic antigen-related cell adhesion molecule 1, MALONIC ACID, octyl beta-D-glucopyranoside | Authors: | Huang, Y.H, Gandhi, A.K, Russell, A, Kondo, Y, Chen, Q, Petsko, G.A, Blumberg, R.S. | Deposit date: | 2014-07-22 | Release date: | 2014-11-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature, 517, 2015
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1D2H
| CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLHOMOCYSTEINE | Descriptor: | GLYCINE N-METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Huang, Y, Komoto, J, Takusagawa, F, Konishi, K, Takata, Y. | Deposit date: | 1999-10-11 | Release date: | 1999-10-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes. J.Mol.Biol., 298, 2000
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3HTX
| Crystal structure of small RNA methyltransferase HEN1 | Descriptor: | 5'-R(*GP*AP*UP*UP*UP*CP*UP*CP*UP*CP*UP*GP*CP*AP*AP*GP*CP*GP*AP*AP*AP*G)-3', 5'-R(P*UP*UP*CP*GP*CP*UP*UP*GP*CP*AP*GP*AP*GP*AP*GP*AP*AP*AP*UP*CP*AP*C)-3', HEN1, ... | Authors: | Huang, Y, Ji, L.-J, Huang, Q.-C, Vassylyev, D.G, Chen, X.-M, Ma, J.-B. | Deposit date: | 2009-06-12 | Release date: | 2009-09-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural insights into mechanisms of the small RNA methyltransferase HEN1. Nature, 461, 2009
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8GTC
| Cryo-EM model of the marine siphophage vB_DshS-R4C baseplate-tail complex | Descriptor: | Distal tail protein, Hub protein, Major tail protein, ... | Authors: | Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N. | Deposit date: | 2022-09-08 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structure and proposed DNA delivery mechanism of a marine roseophage. Nat Commun, 14, 2023
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7RMQ
| Crystal structure of cycloviolacin O2 | Descriptor: | Cycloviolacin O2, D-[I11L]cycloviolacin O2, FORMIC ACID | Authors: | Huang, Y.H, Du, Q. | Deposit date: | 2021-07-28 | Release date: | 2021-09-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.17 Å) | Cite: | Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides. Molecules, 26, 2021
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7RMS
| Crystal structure of [I11G]cycloviolacin O2 | Descriptor: | D-[I11L]cycloviolacin O2, THIOCYANATE ION, [I11L]cycloviolacin O2 | Authors: | Huang, Y.H, Du, Q, Craik, D.J. | Deposit date: | 2021-07-28 | Release date: | 2021-09-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides. Molecules, 26, 2021
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7RMR
| Crystal structure of [I11L]cycloviolacin O2 | Descriptor: | D-[I11L]cycloviolacin O2, THIOCYANATE ION, [I11L]cycloviolacin O2 | Authors: | Huang, Y.H, Du, Q, Craik, D.J. | Deposit date: | 2021-07-28 | Release date: | 2021-09-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides. Molecules, 26, 2021
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8GTB
| Cryo-EM structure of the marine siphophage vB_DshS-R4C tail tube protein | Descriptor: | Major tail protein | Authors: | Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N. | Deposit date: | 2022-09-08 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Structure and proposed DNA delivery mechanism of a marine roseophage. Nat Commun, 14, 2023
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8GTD
| Cryo-EM model of the marine siphophage vB_DshS-R4C portal-adaptor complex | Descriptor: | Head-to-tail joining protein, Portal protein | Authors: | Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N. | Deposit date: | 2022-09-08 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structure and proposed DNA delivery mechanism of a marine roseophage. Nat Commun, 14, 2023
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8GTF
| Cryo-EM model of the marine siphophage vB_DshS-R4C stopper-terminator complex | Descriptor: | Head-to-tail joining protein, Major tail protein, Terminator protein | Authors: | Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N. | Deposit date: | 2022-09-08 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structure and proposed DNA delivery mechanism of a marine roseophage. Nat Commun, 14, 2023
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5YKD
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1I4O
| CRYSTAL STRUCTURE OF THE XIAP/CASPASE-7 COMPLEX | Descriptor: | BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, CASPASE-7 | Authors: | Huang, Y, Park, Y.C, Rich, R.L, Segal, D, Myszka, D.G, Wu, H. | Deposit date: | 2001-02-22 | Release date: | 2001-03-21 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell(Cambridge,Mass.), 104, 2001
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