8OSK

Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map)

Summary for 8OSK

• Entry DOI: 10.2210/pdb8osk/pdb
• EMDB information: 17154 17157 17158
• Descriptor: Histone H3.1, Histone H4, Histone H2A type 1-B/E, ... (8 entities in total)
• Functional Keywords: e-box, transcription factor, circadian clock, gene regulation
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 293913.33

Authors

Stoos, L.,Michael, A.K.,Kempf, G.,Cavadini, S.,Thoma, N.H. (deposition date: 2023-04-19, release date: 2023-05-24, Last modification date: 2023-07-26)

• Primary citation: Michael, A.K.,Stoos, L.,Crosby, P.,Eggers, N.,Nie, X.Y.,Makasheva, K.,Minnich, M.,Healy, K.L.,Weiss, J.,Kempf, G.,Cavadini, S.,Kater, L.,Seebacher, J.,Vecchia, L.,Chakraborty, D.,Isbel, L.,Grand, R.S.,Andersch, F.,Fribourgh, J.L.,Schubeler, D.,Zuber, J.,Liu, A.C.,Becker, P.B.,Fierz, B.,Partch, C.L.,Menet, J.S.,Thoma, N.H.; Cooperation between bHLH transcription factors and histones for DNA access.; Nature, 619:385-393, 2023; PubMed: 37407816; DOI: 10.1038/s41586-023-06282-3

Experimental method

ELECTRON MICROSCOPY (3.6 Å)