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8OSK

Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, E
(A, E)
Histone H3.1polymer13915719.42UniProt (P68431)
Pfam (PF00125)
Homo sapiens (human)Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l
2B, F
(B, F)
Histone H4polymer10611676.72UniProt (P62805)
Pfam (PF15511)
Homo sapiens (human)
3C, G
(C, G)
Histone H2A type 1-B/Epolymer13314447.82UniProt (P04908)
Pfam (PF00125)
Pfam (PF16211)
Homo sapiens (human)Histone H2A.2,Histone H2A/a,Histone H2A/m
4D, H
(D, H)
Histone H2B type 1-Jpolymer12814088.32UniProt (P06899)
Pfam (PF00125)
Homo sapiens (human)Histone H2B.1,Histone H2B.r,H2B/r
5I
(I)
DNA (124-MER)polymer15346975.91synthetic construct
6J
(J)
DNA (124-MER)polymer15347483.21synthetic construct
7K
(M)
Circadian locomoter output cycles protein kaputpolymer37543768.41UniProt (O08785)
Pfam (PF00010)
Pfam (PF00989)
Pfam (PF14598)
Mus musculus (house mouse)mCLOCK
8L
(N)
Basic helix-loop-helix ARNT-like protein 1polymer38443821.21UniProt (Q9WTL8)
Pfam (PF00989)
Pfam (PF14598)
Pfam (PF00010)
Mus musculus (house mouse)Arnt3,Aryl hydrocarbon receptor nuclear translocator-like protein 1,Brain and muscle ARNT-like 1
Sequence modifications
A, E: 0 - 135 (UniProt: P68431)
PDBExternal DatabaseDetails
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
B, F: 0 - 102 (UniProt: P62805)
PDBExternal DatabaseDetails
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
C, G: 0 - 129 (UniProt: P04908)
PDBExternal DatabaseDetails
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
D, H: 0 - 124 (UniProt: P06899)
PDBExternal DatabaseDetails
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
M: 26 - 395 (UniProt: O08785)
PDBExternal DatabaseDetails
Gly 21-expression tag
Ala 22-expression tag
Met 23-expression tag
Asn 24-expression tag
Pro 25-expression tag
N: 69 - 447 (UniProt: Q9WTL8)
PDBExternal DatabaseDetails
Gly 64-expression tag
Ala 65-expression tag
Met 66-expression tag
Asn 67-expression tag
Pro 68-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight293913.3
All*Total formula weight293913.3
*Water molecules are not included.

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PDB entries from 2024-11-06

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