7W80

Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan

Summary for 7W80

• Entry DOI: 10.2210/pdb7w80/pdb
• Descriptor: Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, ... (4 entities in total)
• Functional Keywords: hypoxia-inducible factor 2, hif-2alpha, arnt, transcription
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 85021.69

Authors

Ren, X.,Diao, X.,Zhuang, J.,Wu, D. (deposition date: 2021-12-07, release date: 2022-09-21, Last modification date: 2023-11-29)

• Primary citation: Ren, X.,Diao, X.,Zhuang, J.,Wu, D.; Structural basis for the allosteric inhibition of hypoxia-inducible factor (HIF)-2 by belzutifan.; Mol.Pharmacol., 2022; PubMed: 36167425; DOI: 10.1124/molpharm.122.000525

Experimental method

X-RAY DIFFRACTION (2.754 Å)