7W80
Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aryl hydrocarbon receptor nuclear translocator | polymer | 384 | 43437.4 | 1 | UniProt (P53762) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598) | Mus musculus (house mouse) | ARNT protein,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF-1-beta,HIF1-beta |
| 2 | B (B) | Endothelial PAS domain-containing protein 1 | polymer | 360 | 41201.0 | 1 | UniProt (P97481) Pfam (PF23171) Pfam (PF00989) Pfam (PF14598) | Mus musculus (house mouse) | EPAS-1,HIF-1-alpha-like factor,HLF,mHLF,HIF-related factor,HRF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha |
| 3 | C (B) | 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile | non-polymer | 383.3 | 1 | Chemie (72Q) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A: 82 - 464 (UniProt: P53762)
B: 3 - 361 (UniProt: P97481)
| PDB | External Database | Details |
|---|---|---|
| Met 81 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 2 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84638.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 383.3 | |
| All* | Total formula weight | 85021.7 |
