7UX2

cryo-EM structure of the Raptor-TFEB-Rag-Ragulator complex

Summary for 7UX2

• Entry DOI: 10.2210/pdb7ux2/pdb
• EMDB information: 26840 26842 26843 26844 26846
• Descriptor: Regulatory-associated protein of mTOR, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (12 entities in total)
• Functional Keywords: mtorc1, tfeb, lysosome biogenesis, autophagy, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 16
• Total formula weight: 496494.20

Authors

Cui, Z.,Hurley, J. (deposition date: 2022-05-04, release date: 2022-11-30, Last modification date: 2023-03-01)

• Primary citation: Cui, Z.,Napolitano, G.,de Araujo, M.E.G.,Esposito, A.,Monfregola, J.,Huber, L.A.,Ballabio, A.,Hurley, J.H.; Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.; Nature, 614:572-579, 2023; PubMed: 36697823; DOI: 10.1038/s41586-022-05652-7

Experimental method

ELECTRON MICROSCOPY (2.9 Å)