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7UX2

cryo-EM structure of the Raptor-TFEB-Rag-Ragulator complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001558biological_processregulation of cell growth
A0001938biological_processpositive regulation of endothelial cell proliferation
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0006974biological_processDNA damage response
A0008361biological_processregulation of cell size
A0009267biological_processcellular response to starvation
A0009410biological_processresponse to xenobiotic stimulus
A0010494cellular_componentcytoplasmic stress granule
A0010506biological_processregulation of autophagy
A0010507biological_processnegative regulation of autophagy
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0030291molecular_functionprotein serine/threonine kinase inhibitor activity
A0030295molecular_functionprotein kinase activator activity
A0030307biological_processpositive regulation of cell growth
A0030425cellular_componentdendrite
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031267molecular_functionsmall GTPase binding
A0031669biological_processcellular response to nutrient levels
A0031929biological_processTOR signaling
A0031931cellular_componentTORC1 complex
A0032008biological_processpositive regulation of TOR signaling
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0035176biological_processsocial behavior
A0038202biological_processTORC1 signaling
A0043025cellular_componentneuronal cell body
A0044877molecular_functionprotein-containing complex binding
A0045672biological_processpositive regulation of osteoclast differentiation
A0045821biological_processpositive regulation of glycolytic process
A0045945biological_processpositive regulation of transcription by RNA polymerase III
A0046889biological_processpositive regulation of lipid biosynthetic process
A0071230biological_processcellular response to amino acid stimulus
A0071233biological_processcellular response to L-leucine
A0071333biological_processcellular response to glucose stimulus
A0071456biological_processcellular response to hypoxia
A0071470biological_processcellular response to osmotic stress
A0071889molecular_function14-3-3 protein binding
A0140767molecular_functionenzyme-substrate adaptor activity
A1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
A1901331biological_processpositive regulation of odontoblast differentiation
A1905857biological_processpositive regulation of pentose-phosphate shunt
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0008104biological_processprotein localization
B0009267biological_processcellular response to starvation
B0010507biological_processnegative regulation of autophagy
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0031625molecular_functionubiquitin protein ligase binding
B0031669biological_processcellular response to nutrient levels
B0032008biological_processpositive regulation of TOR signaling
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0034198biological_processcellular response to amino acid starvation
B0035556biological_processintracellular signal transduction
B0042593biological_processglucose homeostasis
B0042803molecular_functionprotein homodimerization activity
B0043495molecular_functionprotein-membrane adaptor activity
B0046982molecular_functionprotein heterodimerization activity
B0051219molecular_functionphosphoprotein binding
B0061462biological_processprotein localization to lysosome
B0071230biological_processcellular response to amino acid stimulus
B0072657biological_processprotein localization to membrane
B1904263biological_processpositive regulation of TORC1 signaling
B1990130cellular_componentGATOR1 complex
B1990131cellular_componentGtr1-Gtr2 GTPase complex
B1990606molecular_functionmembrane scission GTPase motor activity
B1990877cellular_componentFNIP-folliculin RagC/D GAP
C0000287molecular_functionmagnesium ion binding
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0006351biological_processDNA-templated transcription
C0006915biological_processapoptotic process
C0007264biological_processsmall GTPase-mediated signal transduction
C0008104biological_processprotein localization
C0008380biological_processRNA splicing
C0009267biological_processcellular response to starvation
C0010507biological_processnegative regulation of autophagy
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0019003molecular_functionGDP binding
C0031669biological_processcellular response to nutrient levels
C0032006biological_processregulation of TOR signaling
C0034198biological_processcellular response to amino acid starvation
C0043200biological_processresponse to amino acid
C0043231cellular_componentintracellular membrane-bounded organelle
C0043495molecular_functionprotein-membrane adaptor activity
C0046982molecular_functionprotein heterodimerization activity
C0051020molecular_functionGTPase binding
C0060090molecular_functionmolecular adaptor activity
C0061462biological_processprotein localization to lysosome
C0071230biological_processcellular response to amino acid stimulus
C0072657biological_processprotein localization to membrane
C0140767molecular_functionenzyme-substrate adaptor activity
C1903432biological_processregulation of TORC1 signaling
C1904263biological_processpositive regulation of TORC1 signaling
C1990131cellular_componentGtr1-Gtr2 GTPase complex
C1990606molecular_functionmembrane scission GTPase motor activity
C1990877cellular_componentFNIP-folliculin RagC/D GAP
D0001558biological_processregulation of cell growth
D0001919biological_processregulation of receptor recycling
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005515molecular_functionprotein binding
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005768cellular_componentendosome
D0005886cellular_componentplasma membrane
D0007032biological_processendosome organization
D0007040biological_processlysosome organization
D0008104biological_processprotein localization
D0010874biological_processregulation of cholesterol efflux
D0016020cellular_componentmembrane
D0016197biological_processendosomal transport
D0031669biological_processcellular response to nutrient levels
D0031902cellular_componentlate endosome membrane
D0032008biological_processpositive regulation of TOR signaling
D0032418biological_processlysosome localization
D0035577cellular_componentazurophil granule membrane
D0035579cellular_componentspecific granule membrane
D0038202biological_processTORC1 signaling
D0042632biological_processcholesterol homeostasis
D0043410biological_processpositive regulation of MAPK cascade
D0043495molecular_functionprotein-membrane adaptor activity
D0045121cellular_componentmembrane raft
D0051020molecular_functionGTPase binding
D0060090molecular_functionmolecular adaptor activity
D0060620biological_processregulation of cholesterol import
D0070062cellular_componentextracellular exosome
D0071230biological_processcellular response to amino acid stimulus
D0071986cellular_componentRagulator complex
D0072657biological_processprotein localization to membrane
D0101003cellular_componentficolin-1-rich granule membrane
D0150032biological_processpositive regulation of protein localization to lysosome
D1904263biological_processpositive regulation of TORC1 signaling
D1990877cellular_componentFNIP-folliculin RagC/D GAP
E0001558biological_processregulation of cell growth
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005768cellular_componentendosome
E0005770cellular_componentlate endosome
E0005886cellular_componentplasma membrane
E0008104biological_processprotein localization
E0010008cellular_componentendosome membrane
E0010761biological_processfibroblast migration
E0016020cellular_componentmembrane
E0031902cellular_componentlate endosome membrane
E0032008biological_processpositive regulation of TOR signaling
E0035579cellular_componentspecific granule membrane
E0038202biological_processTORC1 signaling
E0043410biological_processpositive regulation of MAPK cascade
E0060090molecular_functionmolecular adaptor activity
E0070821cellular_componenttertiary granule membrane
E0071230biological_processcellular response to amino acid stimulus
E0071986cellular_componentRagulator complex
E0150116biological_processregulation of cell-substrate junction organization
E1902414biological_processprotein localization to cell junction
E1904263biological_processpositive regulation of TORC1 signaling
E1990877cellular_componentFNIP-folliculin RagC/D GAP
F0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005515molecular_functionprotein binding
F0005765cellular_componentlysosomal membrane
F0005768cellular_componentendosome
F0005770cellular_componentlate endosome
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0008104biological_processprotein localization
F0010008cellular_componentendosome membrane
F0016020cellular_componentmembrane
F0019209molecular_functionkinase activator activity
F0031902cellular_componentlate endosome membrane
F0032006biological_processregulation of TOR signaling
F0032008biological_processpositive regulation of TOR signaling
F0035579cellular_componentspecific granule membrane
F0038202biological_processTORC1 signaling
F0043410biological_processpositive regulation of MAPK cascade
F0060090molecular_functionmolecular adaptor activity
F0070062cellular_componentextracellular exosome
F0070821cellular_componenttertiary granule membrane
F0071230biological_processcellular response to amino acid stimulus
F0071986cellular_componentRagulator complex
F1902414biological_processprotein localization to cell junction
F1904263biological_processpositive regulation of TORC1 signaling
F1990877cellular_componentFNIP-folliculin RagC/D GAP
G0005085molecular_functionguanyl-nucleotide exchange factor activity
G0005515molecular_functionprotein binding
G0005764cellular_componentlysosome
G0005765cellular_componentlysosomal membrane
G0008361biological_processregulation of cell size
G0031902cellular_componentlate endosome membrane
G0032008biological_processpositive regulation of TOR signaling
G0038202biological_processTORC1 signaling
G0043231cellular_componentintracellular membrane-bounded organelle
G0060090molecular_functionmolecular adaptor activity
G0061462biological_processprotein localization to lysosome
G0071230biological_processcellular response to amino acid stimulus
G0071986cellular_componentRagulator complex
G1904263biological_processpositive regulation of TORC1 signaling
G1990877cellular_componentFNIP-folliculin RagC/D GAP
H0005085molecular_functionguanyl-nucleotide exchange factor activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005764cellular_componentlysosome
H0005765cellular_componentlysosomal membrane
H0005829cellular_componentcytosol
H0008361biological_processregulation of cell size
H0009615biological_processresponse to virus
H0010628biological_processpositive regulation of gene expression
H0019079biological_processviral genome replication
H0031902cellular_componentlate endosome membrane
H0032008biological_processpositive regulation of TOR signaling
H0032757biological_processpositive regulation of interleukin-8 production
H0032991cellular_componentprotein-containing complex
H0038202biological_processTORC1 signaling
H0043066biological_processnegative regulation of apoptotic process
H0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
H0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
H0051092biological_processpositive regulation of NF-kappaB transcription factor activity
H0060090molecular_functionmolecular adaptor activity
H0061462biological_processprotein localization to lysosome
H0071230biological_processcellular response to amino acid stimulus
H0071986cellular_componentRagulator complex
H1900182biological_processpositive regulation of protein localization to nucleus
H1904263biological_processpositive regulation of TORC1 signaling
H1905636biological_processpositive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
H1990877cellular_componentFNIP-folliculin RagC/D GAP
H2000117biological_processnegative regulation of cysteine-type endopeptidase activity
I0003924molecular_functionGTPase activity
I0005515molecular_functionprotein binding
I0005525molecular_functionGTP binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005764cellular_componentlysosome
I0005765cellular_componentlysosomal membrane
I0005829cellular_componentcytosol
I0006915biological_processapoptotic process
I0008104biological_processprotein localization
I0009267biological_processcellular response to starvation
I0010507biological_processnegative regulation of autophagy
I0016020cellular_componentmembrane
I0016787molecular_functionhydrolase activity
I0031625molecular_functionubiquitin protein ligase binding
I0031669biological_processcellular response to nutrient levels
I0032008biological_processpositive regulation of TOR signaling
I0033209biological_processtumor necrosis factor-mediated signaling pathway
I0034198biological_processcellular response to amino acid starvation
I0035556biological_processintracellular signal transduction
I0042593biological_processglucose homeostasis
I0042803molecular_functionprotein homodimerization activity
I0043495molecular_functionprotein-membrane adaptor activity
I0046982molecular_functionprotein heterodimerization activity
I0051219molecular_functionphosphoprotein binding
I0061462biological_processprotein localization to lysosome
I0071230biological_processcellular response to amino acid stimulus
I0072657biological_processprotein localization to membrane
I1904263biological_processpositive regulation of TORC1 signaling
I1990130cellular_componentGATOR1 complex
I1990131cellular_componentGtr1-Gtr2 GTPase complex
I1990606molecular_functionmembrane scission GTPase motor activity
I1990877cellular_componentFNIP-folliculin RagC/D GAP
J0000287molecular_functionmagnesium ion binding
J0003924molecular_functionGTPase activity
J0005515molecular_functionprotein binding
J0005525molecular_functionGTP binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005764cellular_componentlysosome
J0005765cellular_componentlysosomal membrane
J0005829cellular_componentcytosol
J0006351biological_processDNA-templated transcription
J0006915biological_processapoptotic process
J0007264biological_processsmall GTPase-mediated signal transduction
J0008104biological_processprotein localization
J0008380biological_processRNA splicing
J0009267biological_processcellular response to starvation
J0010507biological_processnegative regulation of autophagy
J0016020cellular_componentmembrane
J0016787molecular_functionhydrolase activity
J0019003molecular_functionGDP binding
J0031669biological_processcellular response to nutrient levels
J0032006biological_processregulation of TOR signaling
J0034198biological_processcellular response to amino acid starvation
J0043200biological_processresponse to amino acid
J0043231cellular_componentintracellular membrane-bounded organelle
J0043495molecular_functionprotein-membrane adaptor activity
J0046982molecular_functionprotein heterodimerization activity
J0051020molecular_functionGTPase binding
J0060090molecular_functionmolecular adaptor activity
J0061462biological_processprotein localization to lysosome
J0071230biological_processcellular response to amino acid stimulus
J0072657biological_processprotein localization to membrane
J0140767molecular_functionenzyme-substrate adaptor activity
J1903432biological_processregulation of TORC1 signaling
J1904263biological_processpositive regulation of TORC1 signaling
J1990131cellular_componentGtr1-Gtr2 GTPase complex
J1990606molecular_functionmembrane scission GTPase motor activity
J1990877cellular_componentFNIP-folliculin RagC/D GAP
K0001558biological_processregulation of cell growth
K0001919biological_processregulation of receptor recycling
K0005085molecular_functionguanyl-nucleotide exchange factor activity
K0005515molecular_functionprotein binding
K0005764cellular_componentlysosome
K0005765cellular_componentlysosomal membrane
K0005768cellular_componentendosome
K0005886cellular_componentplasma membrane
K0007032biological_processendosome organization
K0007040biological_processlysosome organization
K0008104biological_processprotein localization
K0010874biological_processregulation of cholesterol efflux
K0016020cellular_componentmembrane
K0016197biological_processendosomal transport
K0031669biological_processcellular response to nutrient levels
K0031902cellular_componentlate endosome membrane
K0032008biological_processpositive regulation of TOR signaling
K0032418biological_processlysosome localization
K0035577cellular_componentazurophil granule membrane
K0035579cellular_componentspecific granule membrane
K0038202biological_processTORC1 signaling
K0042632biological_processcholesterol homeostasis
K0043410biological_processpositive regulation of MAPK cascade
K0043495molecular_functionprotein-membrane adaptor activity
K0045121cellular_componentmembrane raft
K0051020molecular_functionGTPase binding
K0060090molecular_functionmolecular adaptor activity
K0060620biological_processregulation of cholesterol import
K0070062cellular_componentextracellular exosome
K0071230biological_processcellular response to amino acid stimulus
K0071986cellular_componentRagulator complex
K0072657biological_processprotein localization to membrane
K0101003cellular_componentficolin-1-rich granule membrane
K0150032biological_processpositive regulation of protein localization to lysosome
K1904263biological_processpositive regulation of TORC1 signaling
K1990877cellular_componentFNIP-folliculin RagC/D GAP
L0001558biological_processregulation of cell growth
L0005085molecular_functionguanyl-nucleotide exchange factor activity
L0005515molecular_functionprotein binding
L0005764cellular_componentlysosome
L0005765cellular_componentlysosomal membrane
L0005768cellular_componentendosome
L0005770cellular_componentlate endosome
L0005886cellular_componentplasma membrane
L0008104biological_processprotein localization
L0010008cellular_componentendosome membrane
L0010761biological_processfibroblast migration
L0016020cellular_componentmembrane
L0031902cellular_componentlate endosome membrane
L0032008biological_processpositive regulation of TOR signaling
L0035579cellular_componentspecific granule membrane
L0038202biological_processTORC1 signaling
L0043410biological_processpositive regulation of MAPK cascade
L0060090molecular_functionmolecular adaptor activity
L0070821cellular_componenttertiary granule membrane
L0071230biological_processcellular response to amino acid stimulus
L0071986cellular_componentRagulator complex
L0150116biological_processregulation of cell-substrate junction organization
L1902414biological_processprotein localization to cell junction
L1904263biological_processpositive regulation of TORC1 signaling
L1990877cellular_componentFNIP-folliculin RagC/D GAP
M0005085molecular_functionguanyl-nucleotide exchange factor activity
M0005515molecular_functionprotein binding
M0005765cellular_componentlysosomal membrane
M0005768cellular_componentendosome
M0005770cellular_componentlate endosome
M0005886cellular_componentplasma membrane
M0005925cellular_componentfocal adhesion
M0008104biological_processprotein localization
M0010008cellular_componentendosome membrane
M0016020cellular_componentmembrane
M0019209molecular_functionkinase activator activity
M0031902cellular_componentlate endosome membrane
M0032006biological_processregulation of TOR signaling
M0032008biological_processpositive regulation of TOR signaling
M0035579cellular_componentspecific granule membrane
M0038202biological_processTORC1 signaling
M0043410biological_processpositive regulation of MAPK cascade
M0060090molecular_functionmolecular adaptor activity
M0070062cellular_componentextracellular exosome
M0070821cellular_componenttertiary granule membrane
M0071230biological_processcellular response to amino acid stimulus
M0071986cellular_componentRagulator complex
M1902414biological_processprotein localization to cell junction
M1904263biological_processpositive regulation of TORC1 signaling
M1990877cellular_componentFNIP-folliculin RagC/D GAP
N0005085molecular_functionguanyl-nucleotide exchange factor activity
N0005515molecular_functionprotein binding
N0005764cellular_componentlysosome
N0005765cellular_componentlysosomal membrane
N0008361biological_processregulation of cell size
N0031902cellular_componentlate endosome membrane
N0032008biological_processpositive regulation of TOR signaling
N0038202biological_processTORC1 signaling
N0043231cellular_componentintracellular membrane-bounded organelle
N0060090molecular_functionmolecular adaptor activity
N0061462biological_processprotein localization to lysosome
N0071230biological_processcellular response to amino acid stimulus
N0071986cellular_componentRagulator complex
N1904263biological_processpositive regulation of TORC1 signaling
N1990877cellular_componentFNIP-folliculin RagC/D GAP
O0005085molecular_functionguanyl-nucleotide exchange factor activity
O0005515molecular_functionprotein binding
O0005737cellular_componentcytoplasm
O0005764cellular_componentlysosome
O0005765cellular_componentlysosomal membrane
O0005829cellular_componentcytosol
O0008361biological_processregulation of cell size
O0009615biological_processresponse to virus
O0010628biological_processpositive regulation of gene expression
O0019079biological_processviral genome replication
O0031902cellular_componentlate endosome membrane
O0032008biological_processpositive regulation of TOR signaling
O0032757biological_processpositive regulation of interleukin-8 production
O0032991cellular_componentprotein-containing complex
O0038202biological_processTORC1 signaling
O0043066biological_processnegative regulation of apoptotic process
O0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
O0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
O0051092biological_processpositive regulation of NF-kappaB transcription factor activity
O0060090molecular_functionmolecular adaptor activity
O0061462biological_processprotein localization to lysosome
O0071230biological_processcellular response to amino acid stimulus
O0071986cellular_componentRagulator complex
O1900182biological_processpositive regulation of protein localization to nucleus
O1904263biological_processpositive regulation of TORC1 signaling
O1905636biological_processpositive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
O1990877cellular_componentFNIP-folliculin RagC/D GAP
O2000117biological_processnegative regulation of cysteine-type endopeptidase activity
P0000785cellular_componentchromatin
P0000976molecular_functiontranscription cis-regulatory region binding
P0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
P0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
P0001892biological_processembryonic placenta development
P0002250biological_processadaptive immune response
P0003677molecular_functionDNA binding
P0003700molecular_functionDNA-binding transcription factor activity
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005737cellular_componentcytoplasm
P0005764cellular_componentlysosome
P0005765cellular_componentlysosomal membrane
P0005829cellular_componentcytosol
P0006355biological_processregulation of DNA-templated transcription
P0006357biological_processregulation of transcription by RNA polymerase II
P0006914biological_processautophagy
P0006959biological_processhumoral immune response
P0007040biological_processlysosome organization
P0009267biological_processcellular response to starvation
P0010508biological_processpositive regulation of autophagy
P0016020cellular_componentmembrane
P0019899molecular_functionenzyme binding
P0032418biological_processlysosome localization
P0034198biological_processcellular response to amino acid starvation
P0045893biological_processpositive regulation of DNA-templated transcription
P0045944biological_processpositive regulation of transcription by RNA polymerase II
P0046983molecular_functionprotein dimerization activity
P0061406biological_processobsolete positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation
P0140367biological_processantibacterial innate immune response
P1905671biological_processregulation of lysosome organization
P1990837molecular_functionsequence-specific double-stranded DNA binding
Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV
ChainResidueDetails
CLYS163-VAL180

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: (Microbial infection) Cleavage; by Coxsackievirus B3 protease 3C => ECO:0000269|PubMed:23434374
ChainResidueDetails
PGLN60
OMET1
BHIS127
ISER16
IGLY17
IHIS127

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9R210
ChainResidueDetails
PSER109
PSER114
PSER466
PSER469
KSER42
KSER56
KSER98
KSER141

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
PSER122
NSER67
BTHR36
BILE164
IGLY19
ITHR21
ITHR36
IILE164

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:30120233, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231
ChainResidueDetails
PSER138
DCYS4
KCYS3
KCYS4

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:21617040, ECO:0000269|PubMed:22343943, ECO:0000269|PubMed:30120233, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231
ChainResidueDetails
PSER142
DLYS31
DLYS60
KLYS20
KLYS31
KLYS60

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231
ChainResidueDetails
PTHR183
DLYS103
DLYS104
KLYS103
KLYS104

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:22576015, ECO:0000269|PubMed:22692423, ECO:0000269|PubMed:23401004, ECO:0000269|PubMed:24081491, ECO:0000269|PubMed:25720963, ECO:0000269|PubMed:30120233, ECO:0000269|PubMed:32753672, ECO:0000269|PubMed:35662396, ECO:0000269|PubMed:36697823
ChainResidueDetails
PSER211
CTHR96
CASP181
JTHR90
JTHR96
JASP181

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: S-(2,3-dicarboxypropyl)cysteine => ECO:0000269|PubMed:35662396
ChainResidueDetails
PCYS212
JGLU94

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:21617040
ChainResidueDetails
PSER332
ILYS244
JHIS178
BLYS220
BLYS230
BLYS244
ILYS142
ILYS220
ILYS230

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:21617040, ECO:0007744|PubMed:23186163
ChainResidueDetails
PSER423
CILE220
JLYS179
JILE220

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
PSER441
JSER219

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
PSER467
JSER2

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER15
JSER15

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q99K70
ChainResidueDetails
CTHR96
JTHR96

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715
ChainResidueDetails
ALYS1097

site_idSWS_FT_FI16
Number of Residues1
DetailsCARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260
ChainResidueDetails
ATHR700

site_idSWS_FT_FI17
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303
ChainResidueDetails
ALYS932
ALYS948

227111

PDB entries from 2024-11-06

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