PDB: 229 件ウェブページステータス検索Chemie searchBIRD

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7O7F	Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist 分子名称: C-C chemokine receptor type 5, C-C motif chemokine 5, Fab antibody fragment heavy chain, ... 著者 Isaikina, P, Tsai, C.-J, Dietz, N.B, Pamula, F, Goldie, K.N, Schertler, G.F.X, Maier, T, Stahlberg, H, Deupi, X, Grzesiek, S. 登録日 2021-04-13 公開日 2021-06-30 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist. Sci Adv, 7, 2021
4RWS	Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target) 分子名称: C-X-C chemokine receptor type 4/Endolysin chimeric protein, Viral macrophage inflammatory protein 2 著者 Qin, L, Kufareva, I, Holden, L, Wang, C, Zheng, Y, Wu, H, Fenalti, G, Han, G.W, Cherezov, V, Abagyan, R, Stevens, R.C, Handel, T.M, GPCR Network (GPCR) 登録日 2014-12-05 公開日 2015-02-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science, 347, 2015
8HNK	CXCR3-DNGi complex activated by CXCL11 分子名称: C-X-C motif chemokine 11, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Jiao, H.Z, Hu, H.L. 登録日 2022-12-08 公開日 2023-11-29 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
8IC0	Cryo-EM structure of CXCL8 bound C-X-C chemokine receptor 1 in complex with Gi heterotrimer 分子名称: C-X-C chemokine receptor type 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Ishimoto, N, Park, J.H, Park, S.Y. 登録日 2023-02-10 公開日 2023-07-19 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 Structural basis of CXC chemokine receptor 1 ligand binding and activation. Nat Commun, 14, 2023
6LFM	Cryo-EM structure of a class A GPCR 分子名称: C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. 登録日 2019-12-03 公開日 2020-09-02 最終更新日 2020-09-16 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
6LFO	Cryo-EM structure of a class A GPCR monomer 分子名称: C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. 登録日 2019-12-03 公開日 2020-09-02 最終更新日 2020-09-16 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
4XT3	Structure of a viral GPCR bound to human chemokine CX3CL1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fractalkine, G-protein coupled receptor homolog US28, ... 著者 Burg, J.S, Jude, K.M, Waghray, D, Garcia, K.C. 登録日 2015-01-22 公開日 2015-03-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.801 Å) 主引用文献 Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Science, 347, 2015
4XT1	Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Fractalkine, ... 著者 Burg, J.S, Jude, K.M, Waghray, D, Garcia, K.C. 登録日 2015-01-22 公開日 2015-03-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.886 Å) 主引用文献 Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Science, 347, 2015
8U1U	Structure of a class A GPCR/agonist complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Sun, D, Johnson, M, Masureel, M. 登録日 2023-09-02 公開日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8. Nat Commun, 14, 2023
7F1R	Cryo-EM structure of the chemokine receptor CCR5 in complex with RANTES and Gi 分子名称: C-C motif chemokine 5,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. 登録日 2021-06-09 公開日 2021-07-14 最終更新日 2021-07-28 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
7F1T	Crystal structure of the human chemokine receptor CCR5 in complex with MIP-1a 分子名称: C-C motif chemokine 3,C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION 著者 Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. 登録日 2021-06-09 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
7F1Q	Cryo-EM structure of the chemokine receptor CCR5 in complex with MIP-1a and Gi 分子名称: C-C motif chemokine 3,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. 登録日 2021-06-09 公開日 2021-07-14 最終更新日 2021-07-28 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
8U4O	Structure of CXCL12-bound CXCR4/Gi complex 分子名称: C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Saotome, K, McGoldrick, L.L, Franklin, M.C. 登録日 2023-09-11 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.29 Å) 主引用文献 Structural insights into CXCR4 modulation and oligomerization Biorxiv, 2024
7XA3	Cryo-EM structure of the CCL2 bound CCR2-Gi complex 分子名称: C-C motif chemokine 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. 登録日 2022-03-17 公開日 2022-08-24 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discov, 8, 2022
5UIW	Crystal Structure of CC Chemokine Receptor 5 (CCR5) in complex with high potency HIV entry inhibitor 5P7-CCL5 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, C-C chemokine receptor type 5,Rubredoxin chimera, C-C motif chemokine 5, ... 著者 Zheng, Y, Qin, L, Han, G.W, Gustavsson, M, Kawamura, T, Stevens, R.C, Cherezov, V, Kufareva, I, Handel, T.M. 登録日 2017-01-15 公開日 2017-06-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.204 Å) 主引用文献 Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. Immunity, 46, 2017
7XBX	Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. 登録日 2022-03-22 公開日 2022-07-13 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv, 8, 2022
7VL9	Cryo-EM structure of the CCL15(26-92) bound CCR1-Gi complex 分子名称: C-C chemokine receptor type 1, CCL15(26-92), CHOLESTEROL, ... 著者 Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. 登録日 2021-10-02 公開日 2022-03-23 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nat.Chem.Biol., 18, 2022
7VLA	Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex 分子名称: C-C chemokine receptor type 1, CCL15(27-92), CHOLESTEROL, ... 著者 Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. 登録日 2021-10-02 公開日 2022-03-23 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nat.Chem.Biol., 18, 2022
5WB2	US28 bound to engineered chemokine CX3CL1.35 and nanobodies 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLESTEROL, ... 著者 Jude, K.M, Burg, J.S, Tsutsumi, N, Miles, T.F, Garcia, K.C. 登録日 2017-06-27 公開日 2018-06-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy. Elife, 7, 2018
6WWZ	Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein 分子名称: C-C chemokine receptor type 6,C-C chemokine receptor type 6, C-C motif chemokine 20, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Wasilko, D.J, Johnson, Z.L, Ammirati, M, Han, S, Wu, H. 登録日 2020-05-09 公開日 2020-06-24 最終更新日 2020-07-01 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20. Nat Commun, 11, 2020
7RKN	Structure of CX3CL1-US28-Gi-scFv16 in OC-state 分子名称: Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ... 著者 Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
7RKM	Structure of CX3CL1-US28-Gi-scFv16 in C-state 分子名称: Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ... 著者 Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
7RKF	Structure of CX3CL1-US28-G11iN18-scFv16 in TL-state 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment scFv16, Fractalkine, ... 著者 Tsutsumi, N, Maeda, S, Qu, Q, Skiniotis, G, Kobilka, B.K, Garcia, K.C. 登録日 2021-07-22 公開日 2022-01-26 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
7SK8	Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, an extracellular Fab, and an intracellular Fab 分子名称: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Atypical chemokine receptor 3, CHOLESTEROL, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022
7SK5	Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab 分子名称: Anti-Fab nanobody, Atypical chemokine receptor 3, CHOLESTEROL, ... 著者 Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G. 登録日 2021-10-19 公開日 2022-07-27 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8, 2022

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