7O7F

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

Summary for 7O7F

• Entry DOI: 10.2210/pdb7o7f/pdb
• EMDB information: 12746
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, C-C chemokine receptor type 5, ... (7 entities in total)
• Functional Keywords: g protein-coupled receptor (gpcr); ccr5; ccl5/rantes; hiv entry; aids; membrane protein structure;, membrane protein, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 7
• Total formula weight: 184436.01

Authors

Isaikina, P.,Tsai, C.-J.,Dietz, N.B.,Pamula, F.,Goldie, K.N.,Schertler, G.F.X.,Maier, T.,Stahlberg, H.,Deupi, X.,Grzesiek, S. (deposition date: 2021-04-13, release date: 2021-06-30, Last modification date: 2022-03-16)

• Primary citation: Isaikina, P.,Tsai, C.J.,Dietz, N.,Pamula, F.,Grahl, A.,Goldie, K.N.,Guixa-Gonzalez, R.,Branco, C.,Paolini-Bertrand, M.,Calo, N.,Cerini, F.,Schertler, G.F.X.,Hartley, O.,Stahlberg, H.,Maier, T.,Deupi, X.,Grzesiek, S.; Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist.; Sci Adv, 7:-, 2021; PubMed: 34134983; DOI: 10.1126/sciadv.abg8685

Experimental method

ELECTRON MICROSCOPY (3.15 Å)