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7O7F

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001664molecular_functionG protein-coupled receptor binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005813cellular_componentcentrosome
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0019003molecular_functionGDP binding
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031749molecular_functionD2 dopamine receptor binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0043434biological_processresponse to peptide hormone
A0043949biological_processregulation of cAMP-mediated signaling
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0060236biological_processregulation of mitotic spindle organization
A0070062cellular_componentextracellular exosome
A1904322biological_processcellular response to forskolin
A1904778biological_processpositive regulation of protein localization to cell cortex
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
C0000165biological_processMAPK cascade
C0001618molecular_functionvirus receptor activity
C0002407biological_processdendritic cell chemotaxis
C0003779molecular_functionactin binding
C0004435molecular_functionphosphatidylinositol phospholipase C activity
C0004930molecular_functionG protein-coupled receptor activity
C0004950molecular_functionchemokine receptor activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005886cellular_componentplasma membrane
C0006816biological_processcalcium ion transport
C0006935biological_processchemotaxis
C0006952biological_processdefense response
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0006968biological_processcellular defense response
C0007166biological_processcell surface receptor signaling pathway
C0007186biological_processG protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007267biological_processcell-cell signaling
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0015026molecular_functioncoreceptor activity
C0016020cellular_componentmembrane
C0016493molecular_functionC-C chemokine receptor activity
C0019722biological_processcalcium-mediated signaling
C0019957molecular_functionC-C chemokine binding
C0023052biological_processsignaling
C0042802molecular_functionidentical protein binding
C0046718biological_processsymbiont entry into host cell
C0060326biological_processcell chemotaxis
C0070098biological_processchemokine-mediated signaling pathway
C0070723biological_processresponse to cholesterol
C0071222biological_processcellular response to lipopolysaccharide
C0071791molecular_functionchemokine (C-C motif) ligand 5 binding
C2000110biological_processnegative regulation of macrophage apoptotic process
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0031681molecular_functionG-protein beta-subunit binding
G0097381cellular_componentphotoreceptor disc membrane
I0005576cellular_componentextracellular region
I0006955biological_processimmune response
I0008009molecular_functionchemokine activity
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGIfFIILLTIDRYLaV
ChainResidueDetails
CSER114-VAL130

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
FTYR217-HIS223

site_idPS00472
Number of Residues42
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFayiarp..LprahIkeYfytsgk..Csnp.AVVFvtrknrqv.CA
ChainResidueDetails
ICYS10-ALA51

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by DPP4
ChainResidueDetails
IPRO2
CALA90-GLN102
CTHR167-ILE198
CGLN261-GLN277

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Methionine sulfoxide => ECO:0000269|PubMed:1380064
ChainResidueDetails
IMET67
ATHR181

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc...) serine; partial => ECO:0000269|PubMed:1380064
ChainResidueDetails
IGLY4
IASP5
CLYS219-ARG235
CGLU302-LEU352

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
CLEU69-TYR89

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
CLEU103-ILE124

site_idSWS_FT_FI6
Number of Residues24
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
CVAL142-PHE166

site_idSWS_FT_FI7
Number of Residues19
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
CVAL199-LEU218

site_idSWS_FT_FI8
Number of Residues24
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
CLEU236-PHE260

site_idSWS_FT_FI9
Number of Residues23
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
CALA278-GLY301

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:10089882
ChainResidueDetails
CTYR3

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:21763489
ChainResidueDetails
CTYR10
CTYR14

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Sulfotyrosine => ECO:0000255
ChainResidueDetails
CTYR15

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphoserine; by BARK1 => ECO:0000269|PubMed:10085131
ChainResidueDetails
CSER336
CSER337
CSER342
CSER349

site_idSWS_FT_FI14
Number of Residues3
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:11323418
ChainResidueDetails
CCYS321
CCYS323
CCYS324

site_idSWS_FT_FI15
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:11733580
ChainResidueDetails
CSER6
CSER7

221371

PDB entries from 2024-06-19

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