7O7F
Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62871) Pfam (PF00400) | Bos taurus (Bovine) | Transducin beta chain 1 |
| 3 | C (C) | C-C chemokine receptor type 5 | polymer | 372 | 42726.2 | 1 | UniProt (P51681) Pfam (PF00001) | Homo sapiens (Human) | C-C CKR-5,CC-CKR-5,CCR-5,CCR5,CHEMR13,HIV-1 fusion coreceptor |
| 4 | D (G) | Guanine nucleotide-binding protein G(T) subunit gamma-T1 | polymer | 74 | 8556.9 | 1 | UniProt (P02698) Pfam (PF00631) | Bos taurus (Bovine) | Transducin gamma chain |
| 5 | E (I) | C-C motif chemokine 5 | polymer | 69 | 7857.1 | 1 | UniProt (P13501) Pfam (PF00048) | Homo sapiens (Human) | EoCP,Eosinophil chemotactic cytokine,SIS-delta,Small-inducible cytokine A5,T cell-specific protein P228,TCP228,T-cell-specific protein RANTES |
| 6 | F (H) | Fab antibody fragment heavy chain | polymer | 221 | 23542.2 | 1 | Mus musculus (house mouse) | ||
| 7 | G (F) | Fab antibody fragment light chain | polymer | 217 | 23921.6 | 1 | Mus musculus (house mouse) |
Sequence modifications
C: 1 - 352 (UniProt: P51681)
I: 0 - 68 (UniProt: P13501)
| PDB | External Database | Details |
|---|---|---|
| Gly 353 | - | expression tag |
| Val 354 | - | expression tag |
| Ala 355 | - | expression tag |
| Gly 356 | - | expression tag |
| Leu 357 | - | expression tag |
| Glu 358 | - | expression tag |
| Val 359 | - | expression tag |
| Leu 360 | - | expression tag |
| Phe 361 | - | expression tag |
| Gln 362 | - | expression tag |
| Gly 363 | - | expression tag |
| Pro 364 | - | expression tag |
| Asp 365 | - | expression tag |
| Tyr 366 | - | expression tag |
| Lys 367 | - | expression tag |
| Asp 368 | - | expression tag |
| Asp 369 | - | expression tag |
| Asp 370 | - | expression tag |
| Asp 371 | - | expression tag |
| Lys 372 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pca 0 | Ala 23 | engineered mutation |
| Gly 1 | Ser 24 | engineered mutation |
| Pro 3 | Tyr 26 | engineered mutation |
| Gly 4 | Ser 27 | engineered mutation |
| Asp 5 | Ser 28 | engineered mutation |
| Ile 6 | Asp 29 | engineered mutation |
| Val 7 | Thr 30 | engineered mutation |
| Leu 8 | Thr 31 | engineered mutation |
| Ala 9 | Pro 32 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 184436.0 | |
| All* | Total formula weight | 184436.0 |
