7O7F
Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (Human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62871) Pfam (PF00400) In PDB | Bos taurus (Bovine) | Transducin beta chain 1 |
3 | C | C-C chemokine receptor type 5 | polymer | 372 | 42726.2 | 1 | UniProt (P51681) Pfam (PF00001) In PDB | Homo sapiens (Human) | C-C CKR-5,CC-CKR-5,CCR-5,CCR5,CHEMR13,HIV-1 fusion coreceptor |
4 | G | Guanine nucleotide-binding protein G(T) subunit gamma-T1 | polymer | 74 | 8556.9 | 1 | UniProt (P02698) Pfam (PF00631) In PDB | Bos taurus (Bovine) | Transducin gamma chain |
5 | I | C-C motif chemokine 5 | polymer | 69 | 7857.1 | 1 | UniProt (P13501) Pfam (PF00048) In PDB | Homo sapiens (Human) | EoCP,Eosinophil chemotactic cytokine,SIS-delta,Small-inducible cytokine A5,T cell-specific protein P228,TCP228,T-cell-specific protein RANTES |
6 | H | Fab antibody fragment heavy chain | polymer | 221 | 23542.2 | 1 | Mus musculus (house mouse) | ||
7 | F | Fab antibody fragment light chain | polymer | 217 | 23921.6 | 1 | Mus musculus (house mouse) |
Sequence modifications
C: 1 - 352 (UniProt: P51681)
I: 0 - 68 (UniProt: P13501)
PDB | External Database | Details |
---|---|---|
Gly 353 | - | expression tag |
Val 354 | - | expression tag |
Ala 355 | - | expression tag |
Gly 356 | - | expression tag |
Leu 357 | - | expression tag |
Glu 358 | - | expression tag |
Val 359 | - | expression tag |
Leu 360 | - | expression tag |
Phe 361 | - | expression tag |
Gln 362 | - | expression tag |
Gly 363 | - | expression tag |
Pro 364 | - | expression tag |
Asp 365 | - | expression tag |
Tyr 366 | - | expression tag |
Lys 367 | - | expression tag |
Asp 368 | - | expression tag |
Asp 369 | - | expression tag |
Asp 370 | - | expression tag |
Asp 371 | - | expression tag |
Lys 372 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Pca 0 | Ala 23 | engineered mutation |
Gly 1 | Ser 24 | engineered mutation |
Pro 3 | Tyr 26 | engineered mutation |
Gly 4 | Ser 27 | engineered mutation |
Asp 5 | Ser 28 | engineered mutation |
Ile 6 | Asp 29 | engineered mutation |
Val 7 | Thr 30 | engineered mutation |
Leu 8 | Thr 31 | engineered mutation |
Ala 9 | Pro 32 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 7 |
Total formula weight | 184436.0 | |
All* | Total formula weight | 184436.0 |