7SK6

Cryo-EM structure of human ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ and an intracellular Fab

Summary for 7SK6

Entry DOI	10.2210/pdb7sk6/pdb
EMDB information	25174
Descriptor	Atypical chemokine receptor 3, Stromal cell-derived factor 1, CID24 Fab light chain, ... (4 entities in total)
Functional Keywords	atypical chemokine receptor, membrane protein, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	102237.32
Authors	Yen, Y.C.,Schafer, C.T.,Gustavsson, M.,Handel, T.M.,Tesmer, J.J.G. (deposition date: 2021-10-19, release date: 2022-07-27)
Primary citation	Yen, Y.C.,Schafer, C.T.,Gustavsson, M.,Eberle, S.A.,Dominik, P.K.,Deneka, D.,Zhang, P.,Schall, T.J.,Kossiakoff, A.A.,Tesmer, J.J.G.,Handel, T.M. Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8:eabn8063-eabn8063, 2022 Cited by PubMed: 35857509 DOI: 10.1126/sciadv.abn8063 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4 Å)

Structure validation