7XA3

Cryo-EM structure of the CCL2 bound CCR2-Gi complex

Summary for 7XA3

• Entry DOI: 10.2210/pdb7xa3/pdb
• EMDB information: 33086
• Descriptor: Isoform B of C-C chemokine receptor type 2, C-C motif chemokine 2, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (6 entities in total)
• Functional Keywords: gpcr, ccr2, chemokine receptor, membrne protein, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 164291.46

Authors

Shao, Z.,Tan, Y.,Shen, Q.,Yao, B.,Hou, L.,Qin, J.,Xu, P.,Mao, C.,Chen, L.,Zhang, H.,Shen, D.,Zhang, C.,Li, W.,Du, X.,Li, F.,Chen, Z.,Jiang, Y.,Xu, H.E.,Ying, S.,Ma, H.,Zhang, Y.,Shen, H. (deposition date: 2022-03-17, release date: 2022-08-24)

• Primary citation: Shao, Z.,Tan, Y.,Shen, Q.,Hou, L.,Yao, B.,Qin, J.,Xu, P.,Mao, C.,Chen, L.N.,Zhang, H.,Shen, D.D.,Zhang, C.,Li, W.,Du, X.,Li, F.,Chen, Z.H.,Jiang, Y.,Xu, H.E.,Ying, S.,Ma, H.,Zhang, Y.,Shen, H.; Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3.; Cell Discov, 8:44-44, 2022; PubMed: 35570218; DOI: 10.1038/s41421-022-00403-4

Experimental method

ELECTRON MICROSCOPY (2.9 Å)