7XA3
Cryo-EM structure of the CCL2 bound CCR2-Gi complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Isoform B of C-C chemokine receptor type 2 | polymer | 360 | 41104.3 | 1 | UniProt (P41597) Pfam (PF00001) | Homo sapiens (human) | C-C CKR-2,CC-CKR-2,CCR-2,CCR2,Monocyte chemoattractant protein 1 receptor,MCP-1-R |
| 2 | B (L) | C-C motif chemokine 2 | polymer | 69 | 7913.2 | 1 | UniProt (P13500) Pfam (PF00048) | Homo sapiens (human) | HC11,Monocyte chemoattractant protein 1,Monocyte chemotactic and activating factor,MCAF,Monocyte chemotactic protein 1,MCP-1,Monocyte secretory protein JE,Small-inducible cytokine A2 |
| 3 | C (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40445.1 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 4 | D (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 365 | 39597.2 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 5 | E (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 6 | F (E) | scFv16 | polymer | 256 | 27370.5 | 1 | Homo sapiens |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 7 - 345 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | conflict |
| Ser 326 | Ala 326 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 346 | - | expression tag |
| Ser 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Gly 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Gly 356 | - | expression tag |
| Gly 357 | - | expression tag |
| Ser 358 | - | expression tag |
| Ser 359 | - | expression tag |
| Gly 360 | - | expression tag |
| Val 361 | - | expression tag |
| Ser 362 | - | expression tag |
| Gly 363 | - | expression tag |
| Trp 364 | - | expression tag |
| Arg 365 | - | expression tag |
| Leu 366 | - | expression tag |
| Phe 367 | - | expression tag |
| Lys 368 | - | expression tag |
| Lys 369 | - | expression tag |
| Ile 370 | - | expression tag |
| Ser 371 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 164291.5 | |
| All* | Total formula weight | 164291.5 |
