8IC0

Cryo-EM structure of CXCL8 bound C-X-C chemokine receptor 1 in complex with Gi heterotrimer

Summary for 8IC0

• Entry DOI: 10.2210/pdb8ic0/pdb
• EMDB information: 35351
• Descriptor: C-X-C chemokine receptor type 1, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: gpcr, chemokine, interleukin, cxcr, membrane protein, membrane protein-immune system complex, membrane protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 163396.54

Authors

Ishimoto, N.,Park, J.H.,Park, S.Y. (deposition date: 2023-02-10, release date: 2023-07-19)

• Primary citation: Ishimoto, N.,Park, J.H.,Kawakami, K.,Tajiri, M.,Mizutani, K.,Akashi, S.,Tame, J.R.H.,Inoue, A.,Park, S.Y.; Structural basis of CXC chemokine receptor 1 ligand binding and activation.; Nat Commun, 14:4107-4107, 2023; PubMed: 37433790; DOI: 10.1038/s41467-023-39799-2

Experimental method

ELECTRON MICROSCOPY (3.41 Å)