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8IC0

Cryo-EM structure of CXCL8 bound C-X-C chemokine receptor 1 in complex with Gi heterotrimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0002407biological_processdendritic cell chemotaxis
A0004918molecular_functioninterleukin-8 receptor activity
A0004930molecular_functionG protein-coupled receptor activity
A0004950molecular_functionchemokine receptor activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006935biological_processchemotaxis
A0006955biological_processimmune response
A0007166biological_processcell surface receptor signaling pathway
A0007186biological_processG protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0009897cellular_componentexternal side of plasma membrane
A0016020cellular_componentmembrane
A0016493molecular_functionC-C chemokine receptor activity
A0016494molecular_functionC-X-C chemokine receptor activity
A0019722biological_processcalcium-mediated signaling
A0019957molecular_functionC-C chemokine binding
A0019959molecular_functioninterleukin-8 binding
A0030593biological_processneutrophil chemotaxis
A0030667cellular_componentsecretory granule membrane
A0031623biological_processreceptor internalization
A0038112biological_processinterleukin-8-mediated signaling pathway
A0070098biological_processchemokine-mediated signaling pathway
B0000287molecular_functionmagnesium ion binding
B0001664molecular_functionG protein-coupled receptor binding
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005813cellular_componentcentrosome
B0005834cellular_componentheterotrimeric G-protein complex
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0016020cellular_componentmembrane
B0019001molecular_functionguanyl nucleotide binding
B0019003molecular_functionGDP binding
B0030496cellular_componentmidbody
B0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0031749molecular_functionD2 dopamine receptor binding
B0031821molecular_functionG protein-coupled serotonin receptor binding
B0043434biological_processresponse to peptide hormone
B0043949biological_processregulation of cAMP-mediated signaling
B0046872molecular_functionmetal ion binding
B0051301biological_processcell division
B0060236biological_processregulation of mitotic spindle organization
B0070062cellular_componentextracellular exosome
B0072678biological_processT cell migration
B1904322biological_processcellular response to forskolin
B1904778biological_processpositive regulation of protein localization to cell cortex
C0001750cellular_componentphotoreceptor outer segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0008283biological_processcell population proliferation
C0016020cellular_componentmembrane
C0030159molecular_functionsignaling receptor complex adaptor activity
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0050909biological_processsensory perception of taste
C0051020molecular_functionGTPase binding
C0060041biological_processretina development in camera-type eye
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C0097381cellular_componentphotoreceptor disc membrane
C1903561cellular_componentextracellular vesicle
D0005515molecular_functionprotein binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0031681molecular_functionG-protein beta-subunit binding
D0048144biological_processfibroblast proliferation
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
F0001525biological_processangiogenesis
F0002237biological_processresponse to molecule of bacterial origin
F0005125molecular_functioncytokine activity
F0005153molecular_functioninterleukin-8 receptor binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0006935biological_processchemotaxis
F0006952biological_processdefense response
F0006954biological_processinflammatory response
F0006955biological_processimmune response
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0008009molecular_functionchemokine activity
F0008201molecular_functionheparin binding
F0008285biological_processnegative regulation of cell population proliferation
F0010628biological_processpositive regulation of gene expression
F0010629biological_processnegative regulation of gene expression
F0019722biological_processcalcium-mediated signaling
F0030155biological_processregulation of cell adhesion
F0030593biological_processneutrophil chemotaxis
F0031328biological_processpositive regulation of cellular biosynthetic process
F0031623biological_processreceptor internalization
F0034976biological_processresponse to endoplasmic reticulum stress
F0035556biological_processintracellular signal transduction
F0042119biological_processneutrophil activation
F0044344biological_processcellular response to fibroblast growth factor stimulus
F0045091biological_processregulation of single stranded viral RNA replication via double stranded DNA intermediate
F0045236molecular_functionCXCR chemokine receptor binding
F0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
F0045766biological_processpositive regulation of angiogenesis
F0048566biological_processembryonic digestive tract development
F0050930biological_processinduction of positive chemotaxis
F0060354biological_processnegative regulation of cell adhesion molecule production
F0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
F0070098biological_processchemokine-mediated signaling pathway
F0071222biological_processcellular response to lipopolysaccharide
F0071347biological_processcellular response to interleukin-1
F0071356biological_processcellular response to tumor necrosis factor
F0090023biological_processpositive regulation of neutrophil chemotaxis
F2000535biological_processregulation of entry of bacterium into host cell
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SGIlLLACISVDRYLaI
ChainResidueDetails
ASER123-ILE139

site_idPS00471
Number of Residues46
DetailsSMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CqCIktyskpFhpKfIkeLrviesGphCantEIIvklsdgrel.CLD
ChainResidueDetails
FCYS7-ASP52

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
CLEU70-SER84
CILE157-ILE171
CLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by MMP9
ChainResidueDetails
FSER1
BASN269
AARG175-ARG199
AASP265-ARG285

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
DCYS68
BTHR181

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
DCYS68
AASP134-LYS154
ACYS221-ARG242
AGLY309-LEU350

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
BLEU175

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:21115486
ChainResidueDetails
BASP200

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
ChainResidueDetails
BALA326

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
BARG178

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
BGLN204

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250
ChainResidueDetails
BCYS351

site_idSWS_FT_FI10
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805
ChainResidueDetails
BGLY2
AASN16

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P10824
ChainResidueDetails
BCYS3

222624

PDB entries from 2024-07-17

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