PDB: 1259 件ウェブページステータス検索Chemie searchBIRD

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5OLO	Structure of the A2A-StaR2-bRIL562-Tozadenant complex at 3.1A obtained from in meso soaking experiments. 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, CHOLESTEROL, ... 著者 Rucktooa, P, Cheng, R.K.Y, Segala, E, Geng, T, Errey, J.C, Brown, G.A, Cooke, R, Marshall, F.H, Dore, A.S. 登録日 2017-07-28 公開日 2018-01-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals. Sci Rep, 8, 2018
7RAN	5-HT2AR bound to a novel agonist in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) 分子名称: (3R)-3-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridin-1-ium, 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), ... 著者 Barros-Alvarez, X, Kim, K, Panova, O, Roth, B.L, Skiniotis, G. 登録日 2021-07-02 公開日 2022-07-06 最終更新日 2022-11-02 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity. Nature, 610, 2022
7R0C	Structure of the AVP-V2R-arrestin2-ScFv30 complex 分子名称: AVP, Arrestin2, ScFv30, ... 著者 Bous, J, Fouillen, A, Trapani, S, Granier, S, Mouillac, B, Bron, P. 登録日 2022-02-01 公開日 2022-09-14 実験手法 ELECTRON MICROSCOPY (4.73 Å) 主引用文献 Structure of the vasopressin hormone-V2 receptor-beta-arrestin1 ternary complex. Sci Adv, 8, 2022
4PHU	Crystal structure of Human GPR40 bound to allosteric agonist TAK-875 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, DIMETHYL SULFOXIDE, Free fatty acid receptor 1,Lysozyme, ... 著者 Srivastava, A, Yano, J.K, Hirozane, Y, Kefala, G, Snell, G, Lane, W, Gruswitz, F, Ivetac, A, Aertgeerts, K, Nguyen, J, Jennings, A, Okada, K. 登録日 2014-05-07 公開日 2014-07-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.332 Å) 主引用文献 High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875. Nature, 513, 2014
2I37	Crystal structure of a photoactivated rhodopsin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Rhodopsin, ... 著者 Lodowski, D.T, Stenkamp, R.E, Salom, D, Le Trong, I, Palczewski, K. 登録日 2006-08-17 公開日 2006-10-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (4.15 Å) 主引用文献 Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc.Natl.Acad.Sci.Usa, 103, 2006
7S0F	Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi protein 分子名称: Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Paknejad, N, Alegre, K.O, Su, M, Lou, J.S, Huang, J, Jordan, K.D, Eng, E.T, Meyerson, J.R, Hite, R.K, Huang, X.Y. 登録日 2021-08-30 公開日 2021-11-17 最終更新日 2021-12-01 実験手法 ELECTRON MICROSCOPY (2.96 Å) 主引用文献 Structural basis and mechanism of activation of two different families of G proteins by the same GPCR. Nat.Struct.Mol.Biol., 28, 2021
7S8O	CryoEM structure of Gi-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 分子名称: (3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. 登録日 2021-09-18 公開日 2021-11-17 最終更新日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.58 Å) 主引用文献 Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
7S8L	CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14 分子名称: Cortistatin 14, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. 登録日 2021-09-18 公開日 2021-11-17 最終更新日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.45 Å) 主引用文献 Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
7S0G	Isoproterenol bound beta1 adrenergic receptor in complex with heterotrimeric Gi/s chimera protein 分子名称: Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Paknejad, N, Alegre, K.O, Su, M, Lou, J.S, Huang, J, Jordan, K.D, Eng, E.T, Meyerson, J.R, Hite, R.K, Huang, X.Y. 登録日 2021-08-30 公開日 2021-11-17 最終更新日 2021-12-01 実験手法 ELECTRON MICROSCOPY (3.86 Å) 主引用文献 Structural basis and mechanism of activation of two different families of G proteins by the same GPCR. Nat.Struct.Mol.Biol., 28, 2021
7S8P	CryoEM structure of Gq-coupled MRGPRX4 with small molecule agonist MS47134 分子名称: Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. 登録日 2021-09-18 公開日 2021-11-17 最終更新日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
7S8M	CryoEM structure of Gi-coupled MRGPRX2 with peptide agonist Cortistatin-14 分子名称: Cortistatin 14, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. 登録日 2021-09-18 公開日 2021-11-17 最終更新日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.54 Å) 主引用文献 Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
7S8N	CryoEM structure of Gq-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 分子名称: (3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. 登録日 2021-09-18 公開日 2021-11-17 最終更新日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
4MBS	Crystal Structure of the CCR5 Chemokine Receptor 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4,4-difluoro-N-[(1S)-3-{(3-exo)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-1-phenylpropyl]cyclohexanecarboxamide, Chimera protein of C-C chemokine receptor type 5 and Rubredoxin, ... 著者 Tan, Q, Zhu, Y, Han, G.W, Li, J, Fenalti, G, Liu, H, Cherezov, V, Stevens, R.C, GPCR Network (GPCR), Zhao, Q, Wu, B. 登録日 2013-08-19 公開日 2013-09-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science, 341, 2013
4LDO	Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody 分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, Camelid Antibody Fragment, L-EPINEPHRINE, ... 著者 Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K. 登録日 2013-06-24 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody. Nature, 502, 2013
4PXZ	Crystal structure of P2Y12 receptor in complex with 2MeSADP 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), CHOLESTEROL, ... 著者 Zhang, J, Zhang, K, Gao, Z.G, Paoletta, S, Zhang, D, Han, G.W, Li, T, Ma, L, Zhang, W, Muller, C.E, Yang, H, Jiang, H, Cherezov, V, Katritch, V, Jacobson, K.A, Stevens, R.C, Wu, B, Zhao, Q, GPCR Network (GPCR) 登録日 2014-03-25 公開日 2014-04-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Agonist-bound structure of the human P2Y12 receptor Nature, 509, 2014
2J4Y	Crystal structure of a rhodopsin stabilizing mutant expressed in mammalian cells 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, RETINAL, RHODOPSIN 著者 Standfuss, J, Xie, G, Edwards, P.C, Burghammer, M, Oprian, D.D, Schertler, G.F.X. 登録日 2006-09-07 公開日 2007-09-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Crystal Structure of a Thermally Stable Rhodopsin Mutant. J.Mol.Biol., 372, 2007
4LDE	Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody 分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid Antibody Fragment, ... 著者 Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K. 登録日 2013-06-24 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody. Nature, 502, 2013
4LDL	Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody 分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 4-[(1R)-1-hydroxy-2-{[1-(4-hydroxyphenyl)-2-methylpropan-2-yl]amino}ethyl]benzene-1,2-diol, Camelid Antibody Fragment, ... 著者 Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K. 登録日 2013-06-24 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody. Nature, 502, 2013
4QKX	Structure of beta2 adrenoceptor bound to a covalent agonist and an engineered nanobody 分子名称: 4-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(2-sulfanylethoxy)phenyl]ethyl}amino)ethyl]benzene-1,2-diol, Beta-2 adrenergic receptor, R9 protein, ... 著者 Weichert, D, Kruse, A.C, Manglik, A, Hiller, C, Zhang, C, Huebner, H, Kobilka, B.K, Gmeiner, P. 登録日 2014-06-10 公開日 2014-07-23 最終更新日 2017-06-28 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Covalent agonists for studying G protein-coupled receptor activation. Proc.Natl.Acad.Sci.USA, 111, 2014
2I35	Crystal structure of rhombohedral crystal form of ground-state rhodopsin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, RETINAL, ... 著者 Stenkamp, R.E, Le Trong, I, Lodowski, D.T, Salom, D, Palczewski, K. 登録日 2006-08-17 公開日 2006-10-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc.Natl.Acad.Sci.Usa, 103, 2006
2I36	Crystal structure of trigonal crystal form of ground-state rhodopsin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, Rhodopsin, ... 著者 Stenkamp, R.E, Le Trong, I, Lodowski, D.T, Salom, D, Palczewski, K. 登録日 2006-08-17 公開日 2006-10-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (4.1 Å) 主引用文献 Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc.Natl.Acad.Sci.Usa, 103, 2006
4S0V	Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant 分子名称: Human Orexin receptor type 2 fusion protein to P. abysii Glycogen Synthase, OLEIC ACID, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone 著者 Yin, J, Kolb, P, Mobarec, J.C, Rosenbaum, D.M. 登録日 2015-01-06 公開日 2015-01-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant. Nature, 519, 2015
4RWS	Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target) 分子名称: C-X-C chemokine receptor type 4/Endolysin chimeric protein, Viral macrophage inflammatory protein 2 著者 Qin, L, Kufareva, I, Holden, L, Wang, C, Zheng, Y, Wu, H, Fenalti, G, Han, G.W, Cherezov, V, Abagyan, R, Stevens, R.C, Handel, T.M, GPCR Network (GPCR) 登録日 2014-12-05 公開日 2015-02-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science, 347, 2015
4RWD	XFEL structure of the human delta opioid receptor in complex with a bifunctional peptide 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, OLEIC ACID, SODIUM ION, ... 著者 Fenalti, G, Zatsepin, N.A, Betti, C, Giguere, P, Han, G.W, Ishchenko, A, Liu, W, Guillemyn, K, Zhang, H, James, D, Wang, D, Weierstall, U, Spence, J.C.H, Boutet, S, Messerschmidt, M, Williams, G.J, Gati, C, Yefanov, O.M, White, T.A, Oberthuer, D, Metz, M, Yoon, C.H, Barty, A, Chapman, H.N, Basu, S, Coe, J, Conrad, C.E, Fromme, R, Fromme, P, Tourwe, D, Schiller, P.W, Roth, B.L, Ballet, S, Katritch, V, Stevens, R.C, Cherezov, V, GPCR Network (GPCR) 登録日 2014-12-02 公開日 2015-01-14 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for bifunctional peptide recognition at human delta-opioid receptor. Nat.Struct.Mol.Biol., 22, 2015
4RWA	Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target) 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Soluble cytochrome b562,Delta-type opioid receptor, bifunctional peptide 著者 Fenalti, G, Zatsepin, N.A, Betti, C, Giguere, P, Han, G.W, Ishchenko, A, Liu, W, Guillemyn, K, Zhang, H, James, D, Wang, D, Weierstall, U, Spence, J.C.H, Boutet, S, Messerschmidt, M, Williams, G.J, Gati, C, Yefanov, O.M, White, T.A, Oberthuer, D, Metz, M, Yoon, C.H, Barty, A, Chapman, H.N, Basu, S, Coe, J, Conrad, C.E, Fromme, R, Fromme, P, Tourwe, D, Schiller, P.W, Roth, B.L, Ballet, S, Katritch, V, Stevens, R.C, Cherezov, V, GPCR Network (GPCR) 登録日 2014-12-01 公開日 2015-01-14 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3.28 Å) 主引用文献 Structural basis for bifunctional peptide recognition at human delta-opioid receptor. Nat.Struct.Mol.Biol., 22, 2015

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