1ALI
 
 | | ALKALINE PHOSPHATASE MUTANT (H412N) | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Ma, L, Tibbitts, T.T, Kantrowitz, E.R. | | Deposit date: | 1995-06-02 | | Release date: | 1995-11-14 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
Protein Sci., 4, 1995
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1ALJ
 | | ALKALINE PHOSPHATASE MUTANT (H412N) | | Descriptor: | ALKALINE PHOSPHATASE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Ma, L, Tibbitts, T.T, Kantrowitz, E.R. | | Deposit date: | 1995-06-02 | | Release date: | 1995-11-14 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
Protein Sci., 4, 1995
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1FA4
 | | ELUCIDATION OF THE PARAMAGNETIC RELAXATION OF HETERONUCLEI AND PROTONS IN CU(II) PLASTOCYANIN FROM ANABAENA VARIABILIS | | Descriptor: | COPPER (II) ION, PLASTOCYANIN | | Authors: | Ma, L, Jorgensen, A.M, Sorensen, G.O, Ulstrup, J, Led, J.J. | | Deposit date: | 2000-07-12 | | Release date: | 2000-08-16 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Elucidation of the Paramagnetic R1 Relaxation of Heteronuclei and Protons in Cu(II) Plastocyanin from Anabaena Variabilis
J.Am.Chem.Soc., 122, 2000
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1HQA
 | | ALKALINE PHOSPHATASE (H412Q) | | Descriptor: | ALKALINE PHOSPHATASE, ZINC ION | | Authors: | Ma, L, Kantrowitz, E.R. | | Deposit date: | 1995-11-30 | | Release date: | 1996-03-08 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Kinetic and X-ray structural studies of a mutant Escherichia coli alkaline phosphatase (His-412-->Gln) at one of the zinc binding sites.
Biochemistry, 35, 1996
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1R6R
 | | Solution Structure of Dengue Virus Capsid Protein Reveals a New Fold | | Descriptor: | Genome polyprotein | | Authors: | Ma, L, Jones, C.T, Groesch, T.D, Kuhn, R.J, Post, C.B. | | Deposit date: | 2003-10-16 | | Release date: | 2004-02-17 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution structure of dengue virus capsid protein reveals another fold
Proc.Natl.Acad.Sci.USA, 101, 2004
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6A2B
 | | Crystal Structure of Xenopus laevis MHC I complex | | Descriptor: | Beta-2-microglobulin, MHC class I antigen, TYR-MET-MET-PRO-ARG-HIS-TRP-PRO-ILE | | Authors: | Ma, L.Z, Xia, C. | | Deposit date: | 2018-06-10 | | Release date: | 2019-10-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | A Glimpse of the Peptide Profile Presentation byXenopus laevisMHC Class I: Crystal Structure of pXela-UAA Reveals a Distinct Peptide-Binding Groove.
J Immunol., 204, 2020
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3LAS
 | | Crystal structure of carbonic anhydrase from streptococcus mutans to 1.4 angstrom resolution | | Descriptor: | GLYCEROL, GUANIDINE, MAGNESIUM ION, ... | | Authors: | Ma, L.-L, Wang, K.-T, Liu, X, Su, X.-D. | | Deposit date: | 2010-01-07 | | Release date: | 2011-01-12 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal structure of carbonic anhydrase from streptococcus mutans to 1.4 angstrom resolution
To be published
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8IFF
 | | Cryo-EM structure of Arabidopsis phytochrome A. | | Descriptor: | 3-[5-[[(3~{R},4~{R})-3-ethyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{H}-pyrrol-2-yl]methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic acid, Phytochrome A | | Authors: | Ma, L, Zhou, C, Wang, J, Guan, Z, Yin, P. | | Deposit date: | 2023-02-17 | | Release date: | 2023-08-02 | | Last modified: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Plant phytochrome A in the Pr state assembles as an asymmetric dimer.
Cell Res., 33, 2023
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7VJV
 | | Human AlkB homolog ALKBH6 in complex with alpha-katoglutarate and Mn | | Descriptor: | 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6, MANGANESE (II) ION | | Authors: | Ma, L, Chen, Z. | | Deposit date: | 2021-09-29 | | Release date: | 2022-02-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural insights into the interactions and epigenetic functions of human nucleic acid repair protein ALKBH6.
J.Biol.Chem., 298, 2022
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7VJS
 | | Human AlkB homolog ALKBH6 in complex with Tris and Ni | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6, NICKEL (II) ION | | Authors: | Ma, L, Chen, Z. | | Deposit date: | 2021-09-28 | | Release date: | 2022-02-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.792 Å) | | Cite: | Structural insights into the interactions and epigenetic functions of human nucleic acid repair protein ALKBH6.
J.Biol.Chem., 298, 2022
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6K8I
 | | Crystal structure of Arabidopsis thaliana CRY2 | | Descriptor: | Cryptochrome-2, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Ma, L, Wang, X, Guan, Z, Yin, P. | | Deposit date: | 2019-06-12 | | Release date: | 2020-05-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.697 Å) | | Cite: | Structural insights into BIC-mediated inactivation of Arabidopsis cryptochrome 2.
Nat.Struct.Mol.Biol., 27, 2020
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8DK4
 | | Peroxisome proliferator-activated receptor gamma in complex with VSP-51-2 | | Descriptor: | 5-(benzylcarbamoyl)-1-[(4-chloro-3-fluorophenyl)methyl]-1H-indole-2-carboxylic acid, Peroxisome proliferator-activated receptor gamma, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | | Authors: | Ma, L, Zhou, X.E, Suino-Powell, K, Hou, N, Zhou, Z, Luo, J, Xu, H.E, Yi, W. | | Deposit date: | 2022-07-02 | | Release date: | 2023-07-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Identification of VSP-51-2 as the Novel and Safe PPAR gamma Modulator: Structure-Based Design, Biological Validation and Crystal Analysis
To Be Published
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4ORB
 | | Crystal structure of mouse calcineurin | | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... | | Authors: | Ma, L, Li, S.J, Wang, J, Wu, J.W, Wang, Z.X. | | Deposit date: | 2014-02-11 | | Release date: | 2015-05-20 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.108 Å) | | Cite: | Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
To be Published
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4ORC
 | | Crystal structure of mammalian calcineurin | | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... | | Authors: | Ma, L, Li, S.J, Wang, J, Wu, J.W, Wang, Z.X. | | Deposit date: | 2014-02-11 | | Release date: | 2015-05-20 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
To be Published
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7XTQ
 | | Cryo-EM structure of the R399-bound GPBAR-Gs complex | | Descriptor: | G-protein coupled bile acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Ma, L, Yang, F, Wu, X, Mao, C, Sun, J, Yu, X, Zhang, Y, Zhang, P. | | Deposit date: | 2022-05-17 | | Release date: | 2022-07-06 | | Last modified: | 2022-08-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6M79
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2PH0
 | | Crystal structure of the Q6D2T7_ERWCT protein from Erwinia carotovora. NESG target EwR41. | | Descriptor: | Uncharacterized protein | | Authors: | Vorobiev, S.M, Neely, H, Seetharaman, J, Chen, C.-X, Cunningham, K, Ma, L.-C, Owens, L, Fang, Y, Xiao, R, Acton, T, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2007-04-10 | | Release date: | 2007-04-24 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure of the Q6D2T7_ERWCT protein from Erwinia carotovora.
To be Published
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1QYI
 | | X-RAY STRUCTURE OF Q8NW41 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ZR25. | | Descriptor: | hypothetical protein | | Authors: | Kuzin, A.P, Edstrom, W, Ma, L.C, Shin, L, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2003-09-10 | | Release date: | 2003-12-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | X-RAY STRUCTURE OF Q8NW41 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ZR25.
To be Published
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1ZNP
 | | X-Ray Crystal Structure of Protein Q8U9W0 from Agrobacterium tumefaciens. Northeast Structural Genomics Consortium Target AtR55. | | Descriptor: | hypothetical protein Atu3615 | | Authors: | Kuzin, A.P, Chen, Y, Forouhar, F, Vorobiev, S.M, Xiao, R, Ma, L.-C, Acton, T, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2005-05-11 | | Release date: | 2005-05-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | X-Ray structure of the hypothetical protein Q8U9W0 from Agrobacterium tumefaciens. Northeast Structural Genomics Consortium target AtR55.
To be Published
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1SBK
 | | X-RAY STRUCTURE OF YDII_ECOLI NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET ER29. | | Descriptor: | Hypothetical protein ydiI, SULFATE ION | | Authors: | Kuzin, A.P, Edstrom, W, Vorobiev, S.M, Lee, I, Forouhar, F, Ma, L, Chiang, Y, Rong, X, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2004-02-10 | | Release date: | 2004-02-24 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-ray Structure of YDII_ECOLI Northeast Structural Genomics Consortium Target ER29
To be Published
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1Z94
 | | X-Ray Crystal Structure of Protein CV1439 from Chromobacterium violaceum. Northeast Structural Genomics Consortium Target CvR12. | | Descriptor: | conserved hypothetical protein | | Authors: | Kuzin, A, Vorobiev, S.M, Yong, W, Forouhar, F, Xio, R, Ma, L.-C, Acton, T, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2005-03-31 | | Release date: | 2005-05-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of the Hypothetical Protein CV1439 from Chromobacterium violaceum. Northeast Structural Genomics Consortium Target CVR12.
To be Published
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2B6E
 | | X-Ray Crystal Structure of Protein HI1161 from Haemophilus influenzae. Northeast Structural Genomics Consortium Target IR63. | | Descriptor: | ACETIC ACID, Hypothetical UPF0152 protein HI1161 | | Authors: | Kuzin, A.P, Benach, J, Chen, Y, Acton, T, Xiao, R, Conover, K, Ma, L.-C, Kellie, R, Cunningham, K.E, Montelione, G, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2005-10-01 | | Release date: | 2005-10-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | X-Ray structure of the different crystal form of the hypothetical UPF0152 protein HI1161: NESG target IR63
TO BE PUBLISHED
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1PP5
 | | Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot | | Descriptor: | microcin J25 | | Authors: | Bayro, M.J, Swapna, G.V.T, Huang, J.Y, Ma, L.-C, Mukhopadhyay, J, Ebright, R.H, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2003-06-16 | | Release date: | 2003-10-28 | | Last modified: | 2012-12-12 | | Method: | SOLUTION NMR | | Cite: | Structure of Antibacterial Peptide Microcin J25: A 21-Residue Lariat Protoknot.
J.Am.Chem.Soc., 125, 2003
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1R57
 | | NMR Solution Structure of a GCN5-like putative N-acetyltransferase from Staphylococcus aureus. Northeast Structural Genomics Consortium Target ZR31 | | Descriptor: | conserved hypothetical protein | | Authors: | Cort, J.R, Acton, T.B, Ma, L, Xiao, R.B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2003-10-09 | | Release date: | 2004-03-09 | | Last modified: | 2019-11-06 | | Method: | SOLUTION NMR | | Cite: | Structure of an acetyl-CoA binding protein from Staphylococcus aureus representing a novel subfamily of GCN5-related N-acetyltransferase-like proteins.
J.STRUCT.FUNCT.GENOM., 9, 2008
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1RZW
 | | The Solution Structure of the Archaeglobus fulgidis protein AF2095. Northeast Structural Genomics Consortium target GR4 | | Descriptor: | Protein AF2095(GR4) | | Authors: | Powers, R, Acton, T.B, Huang, Y.J, Liu, J, Ma, L, Rost, B, Chiang, Y, Cort, J.R, Kennedy, M.A, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2003-12-29 | | Release date: | 2004-11-16 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution structure of Archaeglobus fulgidis peptidyl-tRNA hydrolase (Pth2) provides evidence for an extensive conserved family of Pth2 enzymes in archea, bacteria, and eukaryotes
Protein Sci., 14, 2005
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