7XTQ

Cryo-EM structure of the R399-bound GPBAR-Gs complex

Summary for 7XTQ

• Entry DOI: 10.2210/pdb7xtq/pdb
• EMDB information: 33452
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, gpbar, complex, bile acid, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 141107.84

Authors

Ma, L.,Yang, F.,Wu, X.,Mao, C.,Sun, J.,Yu, X.,Zhang, Y.,Zhang, P. (deposition date: 2022-05-17, release date: 2022-07-06, Last modification date: 2022-08-03)

• Primary citation: Ma, L.,Yang, F.,Wu, X.,Mao, C.,Guo, L.,Miao, T.,Zang, S.K.,Jiang, X.,Shen, D.D.,Wei, T.,Zhou, H.,Wei, Q.,Li, S.,Shu, Q.,Feng, S.,Jiang, C.,Chu, B.,Du, L.,Sun, J.P.,Yu, X.,Zhang, Y.,Zhang, P.; Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.; Proc.Natl.Acad.Sci.USA, 119:e2117054119-e2117054119, 2022; PubMed: 35858343; DOI: 10.1073/pnas.2117054119

Experimental method

ELECTRON MICROSCOPY (3.2 Å)