7S8L
CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14
Summary for 7S8L
Entry DOI | 10.2210/pdb7s8l/pdb |
EMDB information | 24896 |
Descriptor | Mas-related G-protein coupled receptor member X2, Cortistatin 14, Gs-mini-Gq chimera, ... (6 entities in total) |
Functional Keywords | gpcr, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 139956.72 |
Authors | Cao, C.,Fay, J.F.,Gumpper, R.H.,Roth, B.L. (deposition date: 2021-09-18, release date: 2021-11-17, Last modification date: 2021-12-15) |
Primary citation | Cao, C.,Kang, H.J.,Singh, I.,Chen, H.,Zhang, C.,Ye, W.,Hayes, B.W.,Liu, J.,Gumpper, R.H.,Bender, B.J.,Slocum, S.T.,Krumm, B.E.,Lansu, K.,McCorvy, J.D.,Kroeze, W.K.,English, J.G.,DiBerto, J.F.,Olsen, R.H.J.,Huang, X.P.,Zhang, S.,Liu, Y.,Kim, K.,Karpiak, J.,Jan, L.Y.,Abraham, S.N.,Jin, J.,Shoichet, B.K.,Fay, J.F.,Roth, B.L. Structure, function and pharmacology of human itch GPCRs. Nature, 600:170-175, 2021 Cited by PubMed: 34789874DOI: 10.1038/s41586-021-04126-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.45 Å) |
Structure validation
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