7S8L
CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Mas-related G-protein coupled receptor member X2 | polymer | 331 | 37147.0 | 1 | UniProt (Q96LB1) Pfam (PF00001) | Homo sapiens (Human) | |
| 2 | B (A) | Cortistatin 14 | polymer | 14 | 1726.0 | 1 | Pfam (PF03002) UniProt (by SIFTS) (O00230) | Homo sapiens | |
| 3 | C (B) | Gs-mini-Gq chimera | polymer | 246 | 28084.8 | 1 | Homo sapiens (Human) | ||
| 4 | D (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37728.2 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 5 | E (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 6 | F (E) | scFv16 | polymer | 257 | 27409.6 | 1 | Mus musculus (Mouse) |
Sequence modifications
R: 2 - 330 (UniProt: Q96LB1)
C: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 139956.7 | |
| All* | Total formula weight | 139956.7 |
