4PHU
Crystal structure of Human GPR40 bound to allosteric agonist TAK-875
Summary for 4PHU
Entry DOI | 10.2210/pdb4phu/pdb |
Descriptor | Free fatty acid receptor 1,Lysozyme, [(3S)-6-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total) |
Functional Keywords | gpr40, fatty acid binding protein, class a, g-protein coupled receptor, type ii diabetes, tak-875, fasiglifam, fatty acid binding protein-hydrolase complex, fatty acid binding protein/hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : O14842 |
Total number of polymer chains | 1 |
Total formula weight | 55725.92 |
Authors | Srivastava, A.,Yano, J.K.,Hirozane, Y.,Kefala, G.,Snell, G.,Lane, W.,Gruswitz, F.,Ivetac, A.,Aertgeerts, K.,Nguyen, J.,Jennings, A.,Okada, K. (deposition date: 2014-05-07, release date: 2014-07-16, Last modification date: 2023-09-27) |
Primary citation | Srivastava, A.,Yano, J.,Hirozane, Y.,Kefala, G.,Gruswitz, F.,Snell, G.,Lane, W.,Ivetac, A.,Aertgeerts, K.,Nguyen, J.,Jennings, A.,Okada, K. High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875. Nature, 513:124-127, 2014 Cited by PubMed: 25043059DOI: 10.1038/nature13494 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.332 Å) |
Structure validation
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