7S8O
CryoEM structure of Gi-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573
Summary for 7S8O
Entry DOI | 10.2210/pdb7s8o/pdb |
EMDB information | 24899 |
Descriptor | Soluble cytochrome b562,Mas-related G-protein coupled receptor member X2 chimera, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total) |
Functional Keywords | gpcr, signaling protein |
Biological source | Escherichia coli More |
Total number of polymer chains | 5 |
Total formula weight | 170724.22 |
Authors | Cao, C.,Fay, J.F.,Gumpper, R.H.,Roth, B.L. (deposition date: 2021-09-18, release date: 2021-11-17, Last modification date: 2021-12-15) |
Primary citation | Cao, C.,Kang, H.J.,Singh, I.,Chen, H.,Zhang, C.,Ye, W.,Hayes, B.W.,Liu, J.,Gumpper, R.H.,Bender, B.J.,Slocum, S.T.,Krumm, B.E.,Lansu, K.,McCorvy, J.D.,Kroeze, W.K.,English, J.G.,DiBerto, J.F.,Olsen, R.H.J.,Huang, X.P.,Zhang, S.,Liu, Y.,Kim, K.,Karpiak, J.,Jan, L.Y.,Abraham, S.N.,Jin, J.,Shoichet, B.K.,Fay, J.F.,Roth, B.L. Structure, function and pharmacology of human itch GPCRs. Nature, 600:170-175, 2021 Cited by PubMed: 34789874DOI: 10.1038/s41586-021-04126-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.58 Å) |
Structure validation
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