8W4J
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6DCE
| X-ray structure of FIP200 claw domain | Descriptor: | RB1-inducible coiled-coil protein 1, SULFATE ION | Authors: | Su, M.-Y, Hurley, J.H. | Deposit date: | 2018-05-05 | Release date: | 2019-03-06 | Last modified: | 2019-05-01 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Mol. Cell, 74, 2019
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4R8F
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7MGE
| Structure of C9orf72:SMCR8:WDR41 in complex with ARF1 | Descriptor: | ADP-ribosylation factor 1, BERYLLIUM TRIFLUORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Su, M.-Y, Hurley, J.H. | Deposit date: | 2021-04-12 | Release date: | 2021-06-23 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.94 Å) | Cite: | Structural basis for the ARF GAP activity and specificity of the C9orf72 complex. Nat Commun, 12, 2021
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5WQL
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8KHP
| CULLIN3-KLHL22-RBX1 E3 ligase | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch-like protein 22 | Authors: | Su, M.-Y, Su, M.-Y. | Deposit date: | 2023-08-22 | Release date: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme. Structure, 31, 2023
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8DME
| CYP102A1 in Open Conformation | Descriptor: | 6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole, Bifunctional cytochrome P450/NADPH--P450 reductase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Su, M, Xu, H. | Deposit date: | 2022-07-08 | Release date: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Insight into the conformational dynamics of cytochrome P450 CYP102A1 enzyme using Cryo-EM To Be Published
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8DMG
| CYP102A1 in Closed Conformation | Descriptor: | 6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole, Bifunctional cytochrome P450/NADPH--P450 reductase, FLAVIN MONONUCLEOTIDE, ... | Authors: | Su, M, Xu, H. | Deposit date: | 2022-07-08 | Release date: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Insight into the conformational dynamics of cytochrome P450 CYP102A1 enzyme using Cryo-EM To Be Published
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8THK
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8THL
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8KGY
| Human glutamate dehydrogenase I | Descriptor: | Glutamate dehydrogenase 1, mitochondrial | Authors: | Su, M.-Y. | Deposit date: | 2023-08-20 | Release date: | 2023-10-25 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme. Structure, 31, 2023
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2M5V
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2N3P
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2N2G
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8DCS
| Cryo-EM structure of cyanopindolol-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein | Descriptor: | 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. | Deposit date: | 2022-06-17 | Release date: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies. Nat Commun, 13, 2022
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8DCR
| Cryo-EM structure of dobutamine-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein | Descriptor: | DOBUTAMINE, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. | Deposit date: | 2022-06-17 | Release date: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies. Nat Commun, 13, 2022
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5K7B
| Beclin 2 CCD homodimer | Descriptor: | Beclin-2 | Authors: | Su, M, Sinha, S. | Deposit date: | 2016-05-25 | Release date: | 2017-03-08 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy. Protein Sci., 26, 2017
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4XH6
| Crystal structure of proto-oncogene kinase Pim1 bound to hispidulin | Descriptor: | 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one, Serine/threonine-protein kinase pim-1 | Authors: | Su, M.-Y, Chang, C.-I. | Deposit date: | 2015-01-05 | Release date: | 2015-08-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1 J.Nat.Prod., 78, 2015
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5K9L
| Beclin 2 CCD N187L mutant homodimer | Descriptor: | Beclin-2 | Authors: | Su, M, Sinha, S. | Deposit date: | 2016-06-01 | Release date: | 2017-03-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy. Protein Sci., 26, 2017
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7JJO
| Structural Basis of the Activation of Heterotrimeric Gs-protein by Isoproterenol-bound Beta1-Adrenergic Receptor | Descriptor: | Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Su, M, Zhu, L, Zhang, Y, Paknejad, N, Dey, R, Huang, J, Lee, M.Y, Williams, D, Jordan, K.D, Eng, E.T, Ernst, O.P, Meyerson, J.R, Hite, R.K, Walz, T, Liu, W, Huang, X.Y. | Deposit date: | 2020-07-27 | Release date: | 2020-09-02 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound beta 1 -Adrenergic Receptor. Mol.Cell, 80, 2020
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6B9X
| Crystal structure of Ragulator | Descriptor: | Hepatitis B virus x interacting protein, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... | Authors: | SU, M.-Y, Hurley, J.H. | Deposit date: | 2017-10-11 | Release date: | 2017-11-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex. Mol. Cell, 68, 2017
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6V4U
| Cryo-EM structure of SMCR8-C9orf72-WDR41 complex | Descriptor: | Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 | Authors: | Su, M.Y, Hurley, J.H. | Deposit date: | 2019-12-01 | Release date: | 2020-09-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD. Nature, 585, 2020
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4MI8
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5WUC
| Structural basis for conductance through TRIC cation channels | Descriptor: | SODIUM ION, Uncharacterized protein | Authors: | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2016-12-17 | Release date: | 2017-07-12 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis for conductance through TRIC cation channels. Nat Commun, 8, 2017
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5WUD
| Structural basis for conductance through TRIC cation channels | Descriptor: | MAGNESIUM ION, Uncharacterized protein | Authors: | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2016-12-17 | Release date: | 2017-06-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for conductance through TRIC cation channels. Nat Commun, 8, 2017
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