8DCS

Cryo-EM structure of cyanopindolol-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein

Summary for 8DCS

Entry DOI	10.2210/pdb8dcs/pdb
EMDB information	27329
Descriptor	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Nanobody 35, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
Functional Keywords	beta1-adrenergic receptor, cyanopindolol, partial agonist, signaling protein
Biological source	Bos taurus (cattle) More
Total number of polymer chains	5
Total formula weight	163354.28
Authors	Su, M.,Paknejad, N.,Hite, R.K.,Huang, X.Y. (deposition date: 2022-06-17, release date: 2022-07-27)
Primary citation	Su, M.,Paknejad, N.,Zhu, L.,Wang, J.,Do, H.N.,Miao, Y.,Liu, W.,Hite, R.K.,Huang, X.Y. Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies. Nat Commun, 13:4095-4095, 2022 Cited by PubMed: 35835792 DOI: 10.1038/s41467-022-31823-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation