4MI8
Crystal structure of the complex of murine gamma-herpesvirus 68 Bcl-2 homolog M11 and a Beclin 1 BH3 domain-derived peptide
Summary for 4MI8
Entry DOI | 10.2210/pdb4mi8/pdb |
Related | 3DVU |
Descriptor | Bcl-2 homolog (Gene 16?), Beclin-1, SULFATE ION, ... (4 entities in total) |
Functional Keywords | bh3d, bcl-2 family, anti-apoptotic and anti-autophagic activities, viral protein-apoptosis complex, viral protein/apoptosis |
Biological source | Murid herpesvirus 4 (MuHV-4) More |
Cellular location | Cytoplasm . Beclin-1-C 35 kDa: Mitochondrion . Beclin-1-C 37 kDa: Mitochondrion : Q14457 |
Total number of polymer chains | 4 |
Total formula weight | 39380.49 |
Authors | |
Primary citation | Su, M.,Mei, Y.,Sanishvili, R.,Levine, B.,Colbert, C.L.,Sinha, S. Targeting gamma-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy. J.Biol.Chem., 289:8029-8040, 2014 Cited by PubMed: 24443581DOI: 10.1074/jbc.M113.515361 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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