4MI8

Crystal structure of the complex of murine gamma-herpesvirus 68 Bcl-2 homolog M11 and a Beclin 1 BH3 domain-derived peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Bcl-2 homolog (Gene 16?)	polymer	143	16652.9	2	UniProt (P89884) Pfam (PF15286)	Murid herpesvirus 4 (MuHV-4)	M11, M11 protein, V-bcl-2
2	C, D (C, D)	Beclin-1	polymer	26	2845.2	2	UniProt (Q14457) Pfam (PF15285)	Homo sapiens	Coiled-coil myosin-like BCL2-interacting protein, Protein GT197
3	E, F, G, H (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	I, J, K, L (A, B, C, D)	water	water		18.0	133	Chemie (HOH)

Sequence modifications

A, B: 2 - 136 (UniProt: P89884)

PDB	External Database	Details
Met 0	-	expression tag
Ala 1	-	expression tag
His 137	-	expression tag
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag

C, D: 107 - 130 (UniProt: Q14457)

PDB	External Database	Details
Gly 105	-	expression tag
Ser 106	-	expression tag
Glu 120	Gly 120	engineered mutation
Ala 121	Asp 121	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	38996.2
Non-Polymers*	Number of molecules	4
	Total formula weight	384.3
All*	Total formula weight	39380.5

*Water molecules are not included.